Research

Clinical Research

Members of the department of neurological surgery are involved in engaged in clinical research in all of the subspecialty areas and each of the clinical centers.  Below are some representative articles representing clinical research from each of the centers.

Comprehensive Neurovascular Center

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
https://www.nejm.org/doi/10.1056/NEJMoa1713973?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dwww.ncbi.nlm.nih.gov

The Effect of July Admission on Inpatient Morbidity, Mortality, and Discharge Disposition After Endovascular Coiling in Subarachnoid Hemorrhage.
https://www.ncbi.nlm.nih.gov/pubmed/28962954

Flow-Diverting Stents for the Obliteration of Symptomatic, Infectious Cavernous Carotid Artery Aneurysms
https://www.ncbi.nlm.nih.gov/pubmed/28961750

Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes
https://www.ncbi.nlm.nih.gov/pubmed/28655834

Comparison of the Prevalence of Ruptured and Unruptured Cerebral Aneurysms in a Poor Urban Minority Population
https://www.ncbi.nlm.nih.gov/pubmed/28623116

Novel double catheter technique with detachable microcatheter for the treatment of arteriovenousmalformations: A technical note.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234298/

Dilated Superior Ophthalmic Vein: Clinical and Radiographic Features of 113 Cases.
https://www.ncbi.nlm.nih.gov/pubmed/28141624

Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone
https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.116.013372?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345109/

Ticagrelor versus Aspirin in Acute Stroke or TransientIschemic Attack.
https://www.ncbi.nlm.nih.gov/pubmed/27160892

Safety  and efficacy using a detachable tip microcatheter in the embolization of pediatric arteriovenous malformations
https://www.ncbi.nlm.nih.gov/pubmed/24671157

Post-subarachnoid hemorrhage vasospasm in patients with primary headache disorders
https://www.ncbi.nlm.nih.gov/pubmed/23192335

Endovascular treatment strategies for acute ischemic stroke
https://www.ncbi.nlm.nih.gov/pubmed/22111796

Comprehensive Spine Center

A National Analysis on Predictors of Discharge to Rehabilitation after Corrective Surgery for Adolescent Idiopathic Scoliosis
https://www.ncbi.nlm.nih.gov/pubmed/29933335

The Effect of Cigarette Smoking on Wound Complications After Single-Level Posterolateral and Interbody Fusion for Spondylolisthesis.
https://www.ncbi.nlm.nih.gov/pubmed/29803058

Use of Bone Morphogenetic Protein-2 in Vertebral Column Tumor Surgery: A National Investigation.
https://www.ncbi.nlm.nih.gov/pubmed/29733987

Predicting critical care unit-level complications after long-segment fusion procedures for adult spinal deformity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911765/

The Effect of July Admission on Inpatient Morbidity, Mortality, and Discharge Disposition After Endovascular Coiling in Subarachnoid Hemorrhage
https://www.ncbi.nlm.nih.gov/pubmed/28965443

Minimally Invasive Separation Surgery with Intraoperative Stereotactic Guidance: A Feasibility Study.
https://www.ncbi.nlm.nih.gov/pubmed/28939543

Impact of body mass index on 30-day outcomes after spinopelvic fixation surgery
https://www.ncbi.nlm.nih.gov/pubmed/28868188

Case-control study of risk factors for surgical site infection after three-column osteotomy for spine deformity.
https://www.ncbi.nlm.nih.gov/pubmed/28656584

Prognostic Value of Preoperative Nurick Grade and Time with Symptoms in Patients with Cervical Myelopathy and Gait Impairment
https://www.ncbi.nlm.nih.gov/pubmed/28602883

Factors associated with prolonged ventilation and reintubation in adult spinal deformity surgery
https://www.ncbi.nlm.nih.gov/pubmed/28551313

Outcome Relationship After 1 and 2 Level Anterior Cervical Discectomy and Fusion.
https://www.ncbi.nlm.nih.gov/pubmed/28532909

The Nationwide Burden of Neurological Conditions Requiring Emergency Neurosurgery
https://www.ncbi.nlm.nih.gov/pubmed/28327940

Surgical and Teaching Mission to Mongolia: Experience and Lessons
https://www.ncbi.nlm.nih.gov/pubmed/28254543

Thirty-day readmission and reoperation rates after single-level anterior cervical discectomy and fusion versus those after cervical disc replacement
https://www.ncbi.nlm.nih.gov/pubmed/28142261

The Impact of Hospital Teaching Status on Timing of Intervention, Inpatient Morbidity, and Mortality After Surgery for Vertebral Column Fractures with Spinal Cord Injury
https://www.ncbi.nlm.nih.gov/pubmed/27915066

The integration of radiosurgery for the treatment of patients with metastatic spine diseases
https://www.ncbi.nlm.nih.gov/pubmed/24966251

A novel scoring system for assessing Chiari malformation type I treatment outcomes
https://www.ncbi.nlm.nih.gov/pubmed/21849925

Comprehensive Brain Tumor Center

Fractionated stereotactic radiation therapy for brain metastases: a systematicreview with tumour control probability modelling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685131/

ILAE type 3 hippocampal sclerosis in patients with anti-GAD-related epilepsy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484895/

Nocardiosis in 132 patients with cancer: microbiological and clinical analyses
https://www.ncbi.nlm.nih.gov/pubmed/25239419

Dynamic perfusion MRI characteristics of dural metastases and meningiomas: a pilot study characterizing the first-pass wash-in phase beyond relative cerebral  blood volume
https://www.ncbi.nlm.nih.gov/pubmed/21427341

Two cases of spinal meningeal melanocytoma
https://www.ncbi.nlm.nih.gov/pubmed/12455888

Alteration of the cortical motor map in a patient with intractable focal seizures.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737918/

Intra-stimulation discharges: an overlooked cortical electrographicentity triggered by direct electrical stimulation
https://www.ncbi.nlm.nih.gov/pubmed/25266305

An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949083/

Speech-Specific Tuning of Neurons in Human Superior Temporal Gyrus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162511/

Phase reversal technique decreases cortical stimulation time during motor mapping
https://www.ncbi.nlm.nih.gov/pubmed/24679940

Factors affecting successful localization of the central sulcus using the somatosensory evoked potential phase reversal technique
https://www.ncbi.nlm.nih.gov/pubmed/23381491

The variability of stimulus thresholds in electrophysiologic cortical language mapping
https://www.ncbi.nlm.nih.gov/pubmed/21399523

The effects of EEG suppression and anesthetics on stimulus thresholds in functional cortical motor mapping
https://www.ncbi.nlm.nih.gov/pubmed/20117047

Comprehensive Skull/Cranial Base Center

Trends in Management of Intracranial Meningiomas: Analysis of 49,921 Cases from Modern Cohort.
https://www.ncbi.nlm.nih.gov/pubmed/?term=agarwal+v+tumor+link

Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival
https://www.ncbi.nlm.nih.gov/pubmed/26452121

Malignant brainstem gliomas in adults: clinicopathological characteristics and prognostic factors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510613/

Cerebellopontine angle meningiomas: postoperative outcomes in a modern cohort
https://www.ncbi.nlm.nih.gov/pubmed/24289118

Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/29562363

Surgical Treatment of Trigeminal Neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/28600016

Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457609/

Case records of the Massachusetts General Hospital. Case 21-2006. A 61-year-old man with left-sided facial pain
https://www.ncbi.nlm.nih.gov/pubmed/16837683

Multimodality treatment of trigeminal neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/16424684

Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes
https://www.ncbi.nlm.nih.gov/pubmed/12762870

Comprehensive Epilepsy Center

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461182/

Human seizures couple across spatial scales through travelling wave dynamics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382286/

Consistent Mesial Resections in Neocortical Temporal Lobe Epilepsy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039275/

Decision analysis of intracranial monitoring in non-lesional epilepsy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618174/

Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618174/

Neuronal ensemble synchrony during human focal seizures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107409/

Utility of foramen ovale electrodes in mesial temporal lobe epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/24605889

Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754454/

Individualized localization and cortical surface-based registration of intracranial electrodes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288767/

Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288767/

Single-neuron dynamics in human focal epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/21441925

Coalescence and fragmentation of cortical networks during focal seizures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927849/

Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877906/

Are cortical tubers epileptogenic? Evidence from electrocorticography
https://www.ncbi.nlm.nih.gov/pubmed/19125835

Comprehensive Movement Disorders Center

Mechanisms of deep brain stimulation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760496/

Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130975/

Ventral Capsule/Ventral Striatum Deep Brain Stimulation Does Not Consistently Diminish Occipital Cross-Frequency Coupling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770190/

Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698744/

Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851930/

Predictors of Hypomania DuringVentral Capsule/Ventral Striatum Deep Brain Stimulation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770191/

A novel brain stimulation technology provides compatibility with MRI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413880/

Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145431/

Characterizing the spiking dynamics of subthalamic nucleus neurons in Parkinson's disease using generalized linear models
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379030/

Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375018/

Deep brain stimulation for medically refractory life-threatening status dystonicus in children
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734533/

Intra-operative behavioral  tasks in awake humans undergoing deep brain stimulation surgery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182655/

Role of deep brain stimulation in modulating memory formation and recall
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848994/

Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486635/

Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients
https://www.ncbi.nlm.nih.gov/pubmed/15601936

Comprehensive Facial Pain and Hemifacial Spasm Center

Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/29562363

Surgical Treatment of Trigeminal Neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/28600016

Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457609/

Case records of the Massachusetts General Hospital. Case 21-2006. A 61-year-old man with left-sided facial pain
https://www.ncbi.nlm.nih.gov/pubmed/16424684

Multimodality treatment of trigeminal neuralgia
https://www.ncbi.nlm.nih.gov/pubmed/16424684

Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes
https://www.ncbi.nlm.nih.gov/pubmed/12762870

Comprehensive Pediatric Neurosurgery Center

The history of intracranial infections
https://www.ncbi.nlm.nih.gov/pubmed/29992487

Diffusion tensor imaging and ventricle volume quantification in-patients with chronic shunt-treated hydrocephalus: a matched case-control study
Separation of craniopagus twins
https://www.ncbi.nlm.nih.gov/pubmed/29350598

Single incision endoscope-assisted surgery for sagittalcraniosynostosis
https://www.ncbi.nlm.nih.gov/pubmed/28197766

Neurointerventional participation in craniopagus separation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757325/

Use of a customized 3D "basket" to create a solitary split-thickness cranial graft from numerous split fragments in an infant
https://www.ncbi.nlm.nih.gov/pubmed/24950470

History of craniotomy, cranioplasty, and perioperative care
https://www.ncbi.nlm.nih.gov/pubmed/24708162

How to get in and out of the skull: from tumi to "hammer and chisel" to the Gigli saw and the osteoplastic flap
https://www.ncbi.nlm.nih.gov/pubmed/24684341

1,500 years of hydrocephalus treatment--how little it has changed
https://www.ncbi.nlm.nih.gov/pubmed/24036336

Craniocerebral disproportion: a topical review and proposal toward a new definition, diagnosis,  and treatment protocol
https://www.ncbi.nlm.nih.gov/pubmed/23974969

Searching for the seat of the soul and its surgical corridors with a perspective on James L. Poppen, René Descartes, and their contributions.
https://www.ncbi.nlm.nih.gov/pubmed/23500120

Models of functional cerebral localization at the dawning ofmodern neurosurgery--a perspective on these remarkable events.
https://www.ncbi.nlm.nih.gov/pubmed/23416780

Separation of craniopagus conjoined twins with a staged approach
https://www.ncbi.nlm.nih.gov/pubmed/23154370

Infections of the spinal subdural space in children: a series of 11 contemporary cases and review of all published reports. A multinational collaborative effort
https://www.ncbi.nlm.nih.gov/pubmed/23053357

A review of reconstructive materials for use in craniofacial surgery bone fixation materials, bone substitutes, and distractors
https://www.ncbi.nlm.nih.gov/pubmed/22872276

Craniosynostosis: posterior two-third  cranial vault reconstruction using bioresorbable plates and a PDS suture lattice in sagittal and lambdoid synostosis
https://www.ncbi.nlm.nih.gov/pubmed/22872255

The craniopagus malformation: classification and implications for surgical separation
https://www.ncbi.nlm.nih.gov/pubmed/16597654

Craniopagus twins: clinical and surgical management
https://www.ncbi.nlm.nih.gov/pubmed/15197566