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Research

Clinical Research

Clinical-Based Research
Comprehensive Neurovascular Center

Endovascular therapy plus medical therapy result in more favorable functional outcomes
Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging.
Albers G, Marks M, Kemp S, et al.
2018

July admissions had no impact on short-term outcome in patients with subarachnoid hemorrhage (SAH)
The Effect of July admissions on inpatient morbidity, mortality, and discharge disposition after endovascular coiling in subarachnoid hemorrhage.
De la Garza Ramos R, Haranhalli N, Kobets A, Nakhla J, Brook A, Yassari R, Flamm E, Altschul D.
2018

The first case of an IIA treated with a flow-diverting pipeline stent
Flow-diverting stents for the obliteration of symptomatic, infectious cavernous carotid artery aneurysms.
Kobets A, Scoco A, Nakhla J, Brook A, Kinon M, Baxi N, Altschul D.
2018

Ticagrelor demonstrated a similar bleeding profile versus aspirin when treating acute stroke or transient ischemic attack
Risk for major bleeding in patients receiving STET ticagrelor compared with aspirin after transient ischemic attack or acute ischemic stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes).
Easton J, Aunes M, Albers G, et al.
2017

The Prevalence of ruptured and unruptured cerebral aneurysms in an urban population
Comparison of the prevalence of ruptured and unruptured cerebral aneurysms in a poor urban minority population.
Miller T, Altschul D, Baxi N, et al.
2018

A safe and effective technique for the treatment of arteriovenous malformations
Novel double catheter technique with detachable microcatheter for the treatment of arteriovenous malformations: A technical note.
Biswas A, Altschul D, Nakhla J, Echt M, Gordon D.
2016

Presentation, etiology, radiography and visual implications of 113 patients with dilated superior ophthalmic veins
Dilated superior ophthalmic vein: Clinical and radiographic features of 113 cases
Adam C, Shields C, Gutman J, et al.
2017

Determine whether adjunctive aspiration contributes to the clinical benefits of thrombectomy with stent retrievers
Aspiration thrombectomy after intravenous alteplase versus intravenous alteplase alone.
Mocco J, Zaidat O, von Kummer R, et al.
2016

Does intensive blood-pressure lowering in patients with acute cerebral hemorrhage result in a lower death rate or disability than standard reduction?
Intensive blood-pressure lowering in patients with acute cerebral hemorrhage.
Qureshi A, Palesch Y, Barsan W, et al.
2016

The efficacy of ticagrelor versus aspirin in reducing the rate of stroke, myocardial infarction, or death
Ticagrelor versus aspirin in acute stroke or transient ischemic attack.
Johnston S, Amarenco P, Albers G, et al.
2016

Detachable tip microcatheters allow for safe and relaxed injections that permit true circumferential occlusions
Safety and efficacy using a detachable tip microcatheter in the embolization of pediatric arteriovenous malformations.
Altschul D, Paramasivam S, Ortega-Gutierrez S, Fifi J, Berenstein A.
2014

PHD history is associated with an increased rate of ischemic infarcts during admission for SAH
Post-subarachnoid hemorrhage vasospasm in patients with primary headache disorders.
Ellis J, Goldstein H, Meyers P, et al.
2013

State-of-the-art technologies in endovascular intervention for acute ischemic stroke
Endovascular treatment strategies for acute ischemic stroke.
Ellis J, Youngerman B, Higashida R, Altschul D, Meyers P.
2011

Comprehensive Spine Center

Nonroutine discharge more likely in male adolescent patients with idiopathic scoliosis
A national analysis on predictors of discharge to rehabilitation after corrective surgery for adolescent idiopathic scoliosis.
De la Garza Ramos R, Nakhla J, Echt M, et al.
2019

Cigarette smoking impact on wound complications postsurgery for spondylolisthesis
The effect of cigarette smoking on wound complications after single-level posterolateral and interbody fusion for spondylolisthesis.
Echt M, De la Garza Ramos R, Nakhla J, et al.
2018

Rate of BMP-2 use in vertebral column tumor surgery
Use of bone morphogenetic protein-2 in vertebral column tumor surgery: A national investigation.
De la Garza Ramos R, Nakhla J, Echt M, et al.
2018

Who is most at risk of developing a CCU-level complication after ASD surgery?
Predicting critical care unit-level complications after long-segment fusion procedures for adult spinal deformity.
De la Garza-Ramos R, Nakhla J, Gelfand Y, et al.
2018

The impact of obesity on surgery outcomes for adolescent idiopathic scoliosis
Effect of body mass index on surgical outcomes after posterior spinal fusion for adolescent idiopathic scoliosis.
De la Garza Ramos R, Nakhla J, Nasser R, et al.
2017

Minimally invasive separation surgery for spinal metastasis allows for circumferential decompression of the spinal cord
Minimally invasive separation surgery with intraoperative stereotactic guidance: A feasibility study.
Nasser R, Nakhla J, Echt M et al.
2018

Significant differences between obesity classes regarding revision surgery, reoperation, and deep wound infection rates
Impact of body mass index on 30-day outcomes after spinopelvic fixation surgery.
Bhashyam N, De la Garza Ramos R, Nakhla J, et al.
2017

Risk factors for surgical site infection after a three-column osteotomy
Case-control study of risk factors for surgical site infection after three-column osteotomy for spine deformity.
De La Garza Ramos R, Nakhla J, Nasser R, Bhashyam N, Kinon M, Yassari R.
2017

The value of early intervention in patients with cervical myelopathy and gait impairment
Prognostic value of preoperative Nurick grade and time with symptoms in patients with cervical myelopathy and gait impairment.
De la Garza-Ramos R, Ramhmdani S, Kosztowski T, et al.
2017

Risk factors associated with prolonged ventilation and reintubation
Factors associated with prolonged ventilation and reintubation in adult spinal deformity surgery.
De la Garza Ramos R, Nakhla J, Nasser R, et al.
2017

Lower odds of complications following 1- and 2-level ACDF associated with increased surgical volume
Volume-outcome relationship after 1 and 2 level anterior cervical discectomy and fusion.
De la Garza Ramos R, Nakhla J, Nasser R, et al.
2017

Critical neurological conditions carry an important nationwide burden
The nationwide burden of neurological conditions requiring emergency neurosurgery.
De la Garza Ramos R, Goodwin C, Nakhla J, et al.
2017

Medical missions can serve as the perfect medium to create self-sustaining improvement in Mongolia
Surgical and teaching mission to Mongolia: Experience and lessons.
Haranhalli N, Gelfand Y, Abramowicz A, Siyez A, Elahi E, Yassari R.
2017

How do readmission and reoperation rates compare after single-level anterior cervical discectomy and fusion versus after cervical disc replacement?
Thirty-day readmission and reoperation rates after single-level anterior cervical discectomy and fusion versus those after cervical disc replacement.
Bhashyam N, De la Garza Ramos R, Nakhla J, et al.
2017

Teaching hospitals more likely to provide early intervention for SCI patients with vertebral column fractures
The impact of hospital teaching status on timing of intervention, inpatient morbidity, and mortality after surgery for vertebral column fractures with spinal cord injury.
De la Garza Ramos R, Nakhla J, Nasser R, et al.
2017

Integrated radiosurgery can provide better local tumor control in patients with metastatic spine diseases
The integration of radiosurgery for the treatment of patients with metastatic spine diseases.
Sharan A, Szulc A, Krystal J, Yassari R, Laufer I, Bilsky M.
2014

Assessing Chiari malformation type I treatment outcomes
A novel scoring system for assessing Chiari malformation type I treatment outcomes.
Aliaga L, Hekman K, Yassari R, et al.
2012

Comprehensive Brain Tumor Center

Fractionated stereotactic radiation therapy provides high rates of local control for patients with brain metastases
Fractionated stereotactic radiation therapy for brain metastases: A systematic review with tumour control probability modelling.
Baliga S, Garg M, Fox J, et al.
2017

Neuropathologic findings and clinical course of patients with anti-GAD-related epilepsy
ILAE type 3 hippocampal sclerosis in patients with anti-GAD–related epilepsy.
Glover R, DeNiro L, Lasala P, Weidenheim K, Graber J, Boro A.
2015

Diverse Nocardia species can cause secondary infections in patients with cancer
Nocardiosis in 132 patients with cancer: Microbiological and clinical analyses.
Wang H, Seo Y, Lasala P, Tarrand J, Han X.
2014

Relative wash-in time lower in metastases compared with meningiomas
Dynamic perfusion MRI characteristics of dural metastases and meningiomas: A pilot study characterizing the first-pass wash-in phase beyond relative cerebral blood volume.
Lui Y, Malhotra A, Farinhas J, et al.
2011

Immunohistochemical and ultrastructural studies examine cases of spinal meningeal melanocytoma
Two cases of spinal meningeal melanocytoma.
Iida M, Llena J, Suarez M, et al.
2002

Reorganization in human motor cortex the result of ongoing focal epileptic activity or lesioning of the postcentral gyrus
Alteration of the cortical motor map in a patient with intractable focal seizures.
Lado F, Legatt A, Lasala P, Shinner S.
2002

Increased probability of intrastimulation discharges with longer stimulations, higher currents, and the presence of BEDs at the stimulation site
Intra-stimulation discharges: an overlooked cortical electrographic entity triggered by direct electrical stimulation.
Karakis I, Leeman-Markowski B, Leveroni C, et al.
2015

An electrocorticography grid with conductive nanoparticles in a polymer thick film on an organic substrate improves CT and MR imaging
An electrocorticography grid with conductive nanoparticles in a polymer thick film on an organic substrate improves CT and MR imaging.
Ahmadi E, Katnani H, Daftari Besheli L, et al.
2016

Speech-specific tuning of neurons in human superior temporal gyrus
Speech-specific tuning of neurons in human superior temporal gyrus.
Chan A, Dykstra A, Jayaram V, et al.
2013

Decreasing cortical stimulation time during motor mapping
Phase reversal technique decreases cortical stimulation time during motor mapping.
Simon M, Sheth S, Eckhardt C, et al.
2014

MSSEP PRT is an effective method for central sulcus identification, marginally lengthening operative time
Factors affecting successful localization of the central sulcus using the somatosensory evoked potential phase reversal technique.
Sheth S, Eckhardt C, Walcott B, Eskandar E, Simon M.
2013

Stimulus thresholds in electrophysiologic cortical language mapping dependent on the lobar location
The variability of stimulus thresholds in electrophysiologic cortical language mapping.
Wang S, Eskandar E, Kilbride R, et al.
2011

Building a predictive model for stimulus thresholds in functional cortical motor mapping
The effects of EEG suppression and anesthetics on stimulus thresholds in functional cortical motor mapping.
Simon M, Michaelides C, Wang S, Chiappa K, Eskandar E.
2010

Comprehensive Skull/Cranial Base Center

Trends in management of intracranial meningiomas
Trends in management of intracranial meningiomas: Analysis of 49,921 cases from modern cohort.
Agarwal V, McCutcheon B, Hughes J, et al.
2017

The effect of aggressive and modern therapies on glioblastoma in the elderly
Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.
Babu R, Komisarow J, Agarwal V, et al.
2016

Clinicopathology and prognosis of malignant brainstem gliomas in adults
Malignant brainstem gliomas in adults: Clinicopathological characteristics and prognostic factors.
Babu R, Kranz P, Agarwal V, et al.
2014

Postoperative outcome factors for cerebellopontine angle meningiomas
Cerebellopontine angle meningiomas: Postoperative outcomes in a modern cohort.
Agarwal V, Babu R, Grier J, et al.
2013

Older patient outcomes following microvascular decompression for trigeminal neuralgia
Older patients have better pain outcomes following microvascular decompression for trigeminal neuralgia.
Bick S, Huie D, Sneh G, Eskandar E.
2019

Surgical treatment of trigeminal neuralgia
Surgical treatment of trigeminal neuralgia.
Bick S, Eskandar E.
2017

The importance of neuroimaging in diagnosing central nervous system lymphoma
Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.
Ang J, Khanna A, Walcott B, Kahle K, Eskandar E.
2015

A case study of a 61-year-old man with left-sided facial pain
Case records of the Massachusetts General Hospital. Case 21-2006. A 61-year-old man with left-sided facial pain.
Eskandar E, Barker FG 2nd, Rabinov J.
2006

Multimodality treatment of trigeminal neuralgia
Multimodality treatment of trigeminal neuralgia.
Amirnovin R, Neimat J, Roberts J, Eskandar E.
2005

Microvascular decompression surgery mortality rates, morbidity rates, and the effects of hospital and surgeon volumes
Microvascular decompression surgery in the United States, 1996 to 2000: Mortality rates, morbidity rates, and the effects of hospital and surgeon volumes.
Kalkanis S, Eskandar E, Carter B, Barker FJ 2nd.
2003

Comprehensive Epilepsy Center

Early development of occult hippocampal hyperexcitability may contribute to Alzheimer’s disease
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease.
Lam A, Deck G, Goldman A, Eskandar E, Noebels J, Cole A.
2017

Human seizures couple across spatial scales through travelling wave dynamics
Human seizures couple across spatial scales through travelling wave dynamics.
Martinet L, Fiddyment G, Madsen J, et al.
2017

Consistent mesial resections in neocortical temporal lobe epilepsy
Hippocampography guides consistent mesial resections in neocortical temporal lobe epilepsy.
Ng M, Kilbride R, Simon M, Eskandar E, Cole A.
2016

Intracranial monitoring is favored over VNS and medical management in young and elderly patients
Decision analysis of intracranial monitoring in non-lesional epilepsy.
Hotan G, Struck A, Bianchi M, Eskandar E, Cole A, Westover M.
2016

Early seizure propagation in neocortex is characterized by a succession of consistent, discrete stages
Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.
Wagner F, Eskandar E, Cosgrove G, et al.
2015

Fine neuronal ensemble synchrony occurs mostly during spike-wave complexes
Neuronal ensemble synchrony during human focal seizures.
Truccolo W, Ahmed O, Harrison M, et al.
2014

Foramen ovale electrodes investigations are effective in evaluating mesial temporal lobe epilepsy
Utility of foramen ovale electrodes in mesial temporal lobe epilepsy.
Sheth S, Aronson J, Shafi M, et al.
2014

Prognostic tool for coma recovery and treatment of status epilepticus
Local cortical dynamics of burst suppression in the anaesthetized brain.
Lewis L, Ching S, Weiner V, et al.
2013

A method for localizing intracranial electrodes
Individualized localization and cortical surface-based registration of intracranial electrodes.
Dykstra A, Chan A, Quinn B, et al.
2012

Neuronal spiking activity in human focal epilepsy
Single-neuron dynamics in human focal epilepsy.
Truccolo W, Donoghue J, Hochberg L, et al.
2011

Epilepsy can be viewed as a manifestation of network reorganization
Coalescence and fragmentation of cortical networks during focal seizures.
Kramer M, Eden U, Kolaczyk E, Zepeda R, Eskandar E, Cash S.
2010

Neuronal firing patterns during interictal discharges in patients with focal seizures
Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.
Keller C, Truccolo W, Gale J, et al.
2010

Are cortical tubers epileptogenic evidence?
Are cortical tubers epileptogenic? Evidence from electrocorticography.
Major P, Rakowski S, Simon M. et al.
2009

Comprehensive Movement Disorders Center

Mechanisms of deep brain stimulation
Mechanisms of deep brain stimulation.
Herrington T, Cheng J, Eskandar E.
2016

Intermittent subthalamic nucleus deep brain stimulation alters decisions and biases behavior
Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects.
Patel S, Herrington T, Sheth S, et al.
2018

Deep brain stimulation impact on occipital cross-frequency coupling
Ventral capsule/ventral striatum deep brain stimulation does not consistently diminish occipital cross-frequency coupling.
Widge A, Zorowitz S, Link K, et al.
2016

Temporally coordinated deep brain stimulation enhances associative learning
Temporally coordinated deep brain stimulation in the dorsal and ventral striatum synergistically enhances associative learning.
Katnani H, Patel S, Kwon C, Abdel-Aziz S, Gale J, Eskandar E.
2016

Patient-specific approach can enhance deep brain stimulation efficacy in treating obsessive compulsive disorder
Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): Precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD).
Makris N, Rathi Y, Mouradian P, et al.
2016

Predictors of hypomania during deep brain stimulation
Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation.
Widge A, Licon E, Zorowitz S, et al.
2016

Brain stimulation technology compatible with MRI
A novel brain stimulation technology provides compatibility with MRI.
Serano P, Angelone L, Katnani H, Eskandar E, Bonmassar G.
2015

Stereotactic neurosurgery guidelines for psychiatric disorders
Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders.
Nuttin B, Wu H, Mayberg H, et al.
2014

The point process model characterizes the dynamics of subthalamic nucleus neurons
Characterizing the spiking dynamics of subthalamic nucleus neurons in Parkinson's disease using generalized linear models.
Eden U, Gale J, Amirnovin R, Eskandar E.
2012

How deep brain stimulation informs understanding of obsessive-compulsive disorder
Mechanisms of deep brain stimulation for obsessive compulsive disorder: Effects upon cells and circuits.
Bourne S, Eckhardt C, Sheth S, Eskandar E.
2012

Deep brain stimulation effective for medically refractory and life-threatening movement disorders
Deep brain stimulation for medically refractory life-threatening status dystonicus in children.
Walcott B, Nahed B, Kahle K, Duhaime A, Sharma N, Eskandar E.
2012

Methods for behavioral tasks in awake patients during deep brain stimulation surgery
Intra-operative behavioral tasks in awake humans undergoing deep brain stimulation surgery.
Gale J, Martinez-Rubio C, Sheth S, Eskandar E.
2011

How brain stimulation can modulate memory formation and recall
Role of deep brain stimulation in modulating memory formation and recall.
Hu R, Eskandar E, Williams Z.
2009

Deep brain stimulation for treatment-resistant depression
Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression.
Malone D Jr., Dougherty D, Rezai A, et al.
2009

How visually guided movements impact Parkinson's disease patients
Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients.
Amirnovin R, Williams Z, Cosgrove G, Eskandar E.
2004

Comprehensive Facial Pain and Hemifacial Spasm Center

The Relationship between age and pain outcomes following microvascular decompression for trigeminal neuralgia
Older patients have better pain outcomes following microvascular decompression for trigeminal neuralgia.
Bick S, Huie D, Sneh G, Eskandar E.
2019

Surgical Treatment of Trigeminal Neuralgia
Surgical treatment of trigeminal neuralgia.
Bick S, Eskandar E.
2017

When central nervous system lymphoma presents as trigeminal neuralgia
Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.
Ang J, Khanna A, Walcott B, Kahle K, Eskandar E.
2015

A case study of a 61-year-old man with left-sided facial pain
Case records of the Massachusetts General Hospital. Case 21-2006. A 61-year-old man with left-sided facial pain.
Eskandar E, Barker FG 2nd, Rabinov J.
2006

Multimodality treatment of trigeminal neuralgia
Multimodality treatment of trigeminal neuralgia.
Amirnovin R, Neimat J, Roberts J, Eskandar E.
2005

Microvascular decompression surgery in the United States
Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes.
Kalkanis S, Eskandar E, Carter B, Barker FG 2nd.
2003

Comprehensive Pediatric Neurosurgery Center

The history of intracranial infections
The history of intracranial infections.
Kobets A, Goodrich J.
2018

Diffusion tensor imaging and ventricle volume quantification in patients with chronic shunt-treated hydrocephalus
Diffusion tensor imaging and ventricle volume quantification in patients with chronic shunt-treated hydrocephalus: A matched case-control study.
Tan K, Meiri A, Mowrey W, et al.
2018

Endoscope-assisted surgery for sagittal craniosynostosis
Singleincision endoscope-assisted surgery for sagittal craniosynostosis.
Goodrich J.
2017

Preoperative neuroendovascular techniques may be helpful in craniopagus separation
Neurointerventional participation in craniopagus separation.
Alokaili R, Ahmed M, Al Feryan A, Goodrich J, Aloraidi A.
2015

A 3-D “basket” can create a solitary split-thickness cranial graft from numerous split fragments in infants
Use of a customized 3D “basket” to create a solitary split-thickness cranial graft from numerous split fragments in an infant.
Sandler A, Tepper O, Goodrich J, Nasser R, Biswas A, Abbott R.
2014

A history of craniotomy, cranioplasty, and perioperative care
Introduction: History of craniotomy, cranioplasty, and perioperative care.
Carson L, Goodrich J, Prestigiacomo C.
2014

Tools and techniques used for craniotomy
How to get in and out of the skull: from tumi to “hammer and chisel” to the Gigli saw and the osteoplastic flap.
Goodrich J.
2014

A history of hydrocephalus treatment
1,500 years of hydrocephalus treatment—how little it has changed.
Goodrich J.
2014

A review of craniocerebral disproportion
Craniocerebral disproportion: a topical review and proposal toward a new definition, diagnosis, and treatment protocol.
Sandler A, Goodrich J, Daniels LB 3rd, Biswas A, Abbott R.
2013

A perspective on James L. Poppen, René Descartes, and their contributions
Searching for the seat of the soul and its surgical corridors with a perspective on James L. Poppen, René Descartes, and their contributions.
Goodrich J.
2014

A review of how models of cortical organization spurred modern neurosurgery
Models of functional cerebral localization at the dawning of modern neurosurgery—a perspective on these remarkable events.
Goodrich J.
2014

The separation of craniopagus conjoined twins
Separation of craniopagus conjoined twins with a staged approach.
Staffenberg D, Goodrich J.
2012

Infections of the spinal subdural space in children
Infections of the spinal subdural space in children: A series of 11 contemporary cases and review of all published reports. A multinational collaborative effort.
Sandler A, Thompson D, Goodrich J, et al.
2012

A review of reconstructive materials used in craniofacial surgery
A review of reconstructive materials for use in craniofacial surgery bone fixation materials, bone substitutes, and distractors.
Goodrich J, Sandler A, Tepper O.
2012

Craniosynostosis technique significantly reduces operating times while providing excellent results
Craniosynostosis: Posterior two-third cranial vault reconstruction using bioresorbable plates and a PDS suture lattice in sagittal and lambdoid synostosis.
Goodrich J, Tepper O, Staffenberg D.
2012

Significantly better mortality for total craniopagus twins in multistaged surgical separation versus single-staged separation
The craniopagus malformation: Classification and implications for surgical separation.
Stone J, Goodrich J.
2006

Craniopagus twins: Clinical and surgical management
Craniopagus twins: Clinical and surgical management.
Goodrich J, Staffenberg D.
2004