Clinical Trials

A clinical trial is a research study in which patients volunteer to test the effectiveness of a technique to diagnose, treat or possibly even prevent a medical condition. Not all individuals are eligible for clinical trials, but those who are and who agree to take part after discussions with their doctors are making important contributions to medical science.

Montefiore offers access to several clinical trials testing diagnostic techniques and treatment methods for Alzheimer’s Disease:

  • Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
    https://clinicaltrials.gov/ct2/show/NCT03043573
    The study aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs. Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in improving cognitive, affective and functioning outcomes. Psychotherapy, also known as talking therapy, is the use of psychological methods to help a person change and overcome problems in desired ways. PATH-MCI differs from standard of care psychotherapy by offering a combination of emotion regulation techniques with the provision of environmental adaptation tools (notes, checklists, calendars, etc.), the use of the WellPATH app, and the participation of a willing and available caregiver.
    A second study of the PATH methodology, funded by the Leslie R. Samuels and Fan Fox Foundation, is directed at frail older adults who are high risk for cognitive impairment and depression and who have chronic kidney disease. This study is an in-home or office-based counseling program that focuses on the patient, the caregiver and the patient’s home environment to encourage problem-solving and strategies to adapt to memory and functional problems.
  • 5-Cog Battery for Detecting Cognitive Impairment and Dementia (5-Cog)
    https://clinicaltrials.gov/ct2/show/NCT03816644?term=5+Cog&cond=Cognitive+Impairment&cntry=US&state=US%3ANY&draw=2&rank=1
    Cognitive impairment related to dementia is frequently under-diagnosed in primary care settings. To overcome the technical, cultural and logistic barriers of current cognitive screens and dementia care in primary care settings the investigators have developed a 5-minute cognitive screen (5-Cog) coupled with a decision tree to identify persons at high risk of developing dementia in multi-ethnic primary care populations.
    The cognitive assessment will sort patients with “cognitive impairment’ from those with “no cognitive impairment’. The primary objective is to test the ability of the 5-Cog and decision tree paradigm to improve dementia care in primary care patients with cognitive concerns.
  • Movement Intervention for Memory Enhancement (MIME)
    https://clinicaltrials.gov/ct2/show/NCT03475316?term=dancing&recrs=a&age=2&draw=2&rank=1
    Social dancing is a complex sensorimotor rhythmic activity integrating physical, cognitive and social elements with the potential to ameliorate a wide range of physical and cognitive impairments in older individuals at risk of Alzheimer’s disease (AD) and related dementias.
    The study compares social dancing (ballroom dancing) versus active control (walking) in older adults at high risk of dementia. It is designed to provide the evidence base to develop a larger study to support or refute prescription of social dancing to prevent cognitive decline in older adults at high risk of AD and related dementias.
  • Transcranial Direct Current Stimulation (tDCS) in Mild to Moderate Alzheimer’s Disease (AD) Patients
    https://clinicaltrials.gov/ct2/show/NCT04404153
    The prevalence of Alzheimer’s Disease (AD) is rising, but existing medications provide only modest control of cognitive decline and associated symptoms, and novel therapies are urgently needed. This randomized sham-controlled trial will determine if an innovative low-risk remotely-supervised transcranial Direct Current Stimulation (tDCS) applied over the area of the dorsolateral prefrontal cortex for 30 minutes at the intensity of 2 mA five times per week for 6 months at home can improve cognitive performance and symptoms and modulate neuroimaging markers of neuroplasticity in 100 patients with mild to moderate AD. If effective, this novel intervention can substantially enhance AD symptom management at home, improve quality of life of AD patients and their families, and reduce burden associated with this debilitating illness.

For more information about these trials, call Montefiore at 914-375-4880.

The National Institutes of Health has extensive information on Alzheimer’s Disease trials at click here 

The Alzheimer’s Association also has a listing of clinical trials at click here