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Title   Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma
Description   The purpose of this trial is studying giving bortezomib together with dexamethasone, ifosfamide, carboplatin, and etoposide to see how well it works with or without rituximab in treating patients with relapsed or refractory AIDS-related non-Hodgkin lymphoma.

Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. Drugs used in chemotherapy, such as dexamethasone, ifosfamide, carboplatin, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them.

It is not yet known whether giving bortezomib together with combination chemotherapy is more effective with or without rituximab in treating AIDS-related non-Hodgkin lymphoma.
Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patients must be 18 Years and older

* Patient must have histologically or cytologically confirmed relapsed or refractory HIV-associated non-Hodgkin lymphoma (NHL).

* Patient must have a life expectancy of more than 2 months.
Principal Investigator   Samir Parekh, MD
Contact Name   Yoko Eng, NP
Phone   (718) 920-2090
Contact Email
Post Date   01/09/2008
Protocol Number   08-06-200/West
Status   Recruiting
Current Trial Type   Interventional
Adult Clinical Trial   No
Pediatric Clinical Trial   No