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Title   Vorinostat in Combination With Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors and HIV Infection
Disease/Condition   Head and Neck Cancer
Description   The purpose of this trial is to study the side effects and the best dose of vorinostat when given together with paclitaxel and carboplatin in treating patients with metastatic or recurrent solid tumors and HIV infection.

Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

Giving vorinostat together with paclitaxel and carboplatin may kill more tumor cells.
Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patient must be 18 Years and older

* Patient has histologically confirmed solid malignancy meeting 1 of the following criteria:

-Non-small cell lung cancer
-Head and neck squamous cell carcinoma.
- Non-gastroesophageal junction esophageal cancer.
- Solid tumor that is sensitive to carboplatin and/or taxanes including, but not limited to, any of the following (dose-escalation phase only):

-Salivary gland cancer
-Gastric cancer
-Breast cancer
-Ovarian cancer
-Anal cancer
Principal Investigator   Missak Haigentz, MD
Contact Name   Cherly Baker, RN
Phone   (718) 920-8508
Contact Email   cbaker@montefiore.org
Post Date   11/25/2010
Protocol Number   11-01-022/West
Status   Recruiting
Current Trial Type   Interventional
Montefiore Clinical Trial   No
CHAM Clinical Trial   No