Research

Lab-Based Research

The Department of Neurological Surgery at Montefiore and our Albert Einstein College of Medicine has an active and robust lab-based research program, also known as basic science research. The lab-based research consists of individual and collaborative work conducted by basic scientists, physician scientists, and postdoctoral scientists.

Below is a representative list of published research articles from the Department of Neurological Surgery:

Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects
Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects.
Patel S, Herrington T, Sheth S, et al.
2018

Multimodal encoding of novelty, reward, and learning in the primate nucleus basalis of Meynert
Multimodal encoding of novelty, reward, and learning in the primate nucleus basalis of Meynert.
Martinez-Rubio C, Paulk A, McDonald E, Widge A, Eskandar E.
2018

Prefrontal neurons encode a solution to the credit-assignment problem
Prefrontal neurons encode a solution to the credit-assignment problem.
Asaad W, Lauro P, Perge J, Eskandar E
2017

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.
Lam A, Deck G, Goldman A, Eskandar E, Noebels J, Cole A
2017

Hippocampography guides consistent mesial resections in neocortical temporal lobe epilepsy
Hippocampography guides consistent mesial resections in neocortical temporal lobe epilepsy.
Ng M, Kilbride R, Simon M, Eskandar E, Cole A.
2016

Temporally coordinated deep brain stimulation in the dorsal and ventral striatum synergistically enhances associative learning
Temporally coordinated deep brain stimulation in the dorsal and ventral striatum synergistically enhances associative learning.
Katnani H, Patel S, Kwon C, Abdel-Aziz S, Gale J, Eskandar E.
2016

Frequency-dependent representation of reinforcement-related information in the human medial and lateral prefrontal cortex
Frequency-dependent representation of reinforcement-related information in the human medial and lateral prefrontal cortex.
Smith E, Banks G, Mikell C, et al.
2015

Mechanisms of deep brain stimulation
Mechanisms of deep brain stimulation.
Herrington T, Cheng J, Eskandar E.
2016

The utility of foramen ovale electrodes in mesial temporal lobe epilepsy
Utility of foramen ovale electrodes in mesial temporal lobe epilepsy.
Sheth S, Aronson J, Shafi M, et al.
2014

A consensus on guidelines for stereotactic neurosurgery for psychiatric disorders
Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders.
Nuttin B, Wu H, Mayberg H, et al.
2014

Action initiation in the human dorsal anterior cingulate cortex
Action initiation in the human dorsal anterior cingulate cortex.
Srinivasan L, Asaad W, Ginat D, et al.
2013

The encoding of rules by neurons in the human dorsolateral prefrontal cortex
Encoding of rules by neurons in the human dorsolateral prefrontal cortex.
Mian M, Sheth S, Patel S, Spiliopoulos K, Eskandar E, Williams Z.
2012

Human dorsal anterior cingulate cortex neurons mediate ongoing behavioral adaptation
Human dorsal anterior cingulate cortex neurons mediate ongoing behavioral adaptation.
Sheth S, Mian M, Patel S, et al.
2012

Mechanisms of deep brain stimulation for obsessive compulsive disorder: Effects upon cells and circuits
Mechanisms of deep brain stimulation for obsessive compulsive disorder: Effects upon cells and circuits.
Bourne S, Eckhardt C, Sheth S, Eskandar E.
2012

Single-neuron responses in the human nucleus accumbens during a financial decision-making task
Single-neuron responses in the human nucleus accumbens during a financial decision-making task.
Patel S, Sheth S, Mian M, et al.
2012

An intraoperative, multimodal neurophysiologic approach to successful resection of precentral gyrus epileptogenic lesions
An intraoperative multimodal neurophysiologic approach to successful resection of precentral gyrus epileptogenic lesions.
Simon M, Cole A, Chang E, et al.
2012

Deep brain stimulation for medically refractory life-threatening status dystonicus in children
Deep brain stimulation for medically refractory life-threatening status dystonicus in children.
Walcott B, Nahed B, Kahle K, Duhaime A, Sharma N, Eskandar E.
2012

The encoding of both positive and negative reward prediction errors by neurons of the primate lateral prefrontal cortex and caudate nucleus
Encoding of both positive and negative reward prediction errors by neurons of the primate lateral prefrontal cortex and caudate nucleus.
Asaad W, Eskandar E.
2011

Basal ganglia neurons dynamically facilitate exploration during associative learning
Basal ganglia neurons dynamically facilitate exploration during associative learning.
Sheth S, Abuelem T, Gale J, Eskandar E.
2011

Single-neuron dynamics in human focal epilepsy
Single-neuron dynamics in human focal epilepsy.
Truccolo W, Donoghue J, Hochberg L, et al.
2011

Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression
Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression.
Malone D, Dougherty D, Rezai A, et al.
2009

Are cortical tubers epileptogenic?
Are cortical tubers epileptogenic? Evidence from electrocorticography.
Major P, Rakowski S, Simon M, et al.
2009

Visually guided movements suppress subthalamic oscillations in Parkinson’s disease patients
Visually guided movements suppress subthalamic oscillations in Parkinson’s disease patients.
Amirnovin R., Williams Z, Cosgrove G, Eskandar E.
2004

The Distinct nature of directional signals among parietal cortical areas during visual guidance
Distinct nature of directional signals among parietal cortical areas during visual guidance.
Eskandar E, Assad J.
2002