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Richard N. Kitsis, MD

Practice Specialty
Cardiology (Heart)
Medical Education
University of California
Boston Veterans Administration HealthCare System
Montefiore Medical Center
Main Location
Montefiore Weiler Hospital
1825 Eastchester Road
Bronx, NY 10461-2301
Phone: (718) 430-2609
Fax: (718) 430-8989
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Academic Title
Professor of Medicine and Cell Biology; The Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease; Director, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
Administrative Title
Attending Cardiologist, Montefiore
Research Focus
Dr. Kitsis research deals with how and why heart muscle cells die during myocardial infarction (“heart attack”) and heart failure. His laboratory pioneered this field, and delineated molecular mechanisms responsible for the heart damage that takes place during these two most common and lethal cardiac syndromes. Efforts are now being directed to create new drugs that may limit heart damage during heart attacks with the goal of decreasing subsequent heart failure and mortality.
Wencker D, Chandra M, Nguyen KT, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC, Kitsis RN. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest, 2003. 111: 1497-1504. PMID: 12750399 PMCID: PMC155051

Nam Y-J, Mani K, Ashton AW, Peng C-F, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Molecular Cell, 2004. 15: 901-912. PMID: 15383280

Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L,  Roth KA, Kitsis RN, Scherer PE. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nature Medicine, 2005. 11: 797-803. PMID: 15965483

Kitsis RN, Jialal I. Limiting myocardial damage during acute myocardial infarction by inhibiting C-reactive protein. N Engl J Med, 2006. 355: 513-515. PMID: 16885557 Foo RS-Y, Nam Y-J, Ostreicher MJ, Metzl MD, Whelan RS, Peng C-F, Ashton AW, Fu W, Mani K, Chin S-F, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN. Regulation of p53 tetramerization and nuclear export by ARC. Proc Natl Acad Sci (USA), 2007. 104: 20826-20831. PMID: 18087040 PMCID: PMC2409226

Wu L, Nam Y-J, Kung G, Crow MT, Kitsis RN. Induction of the apoptosis inhibitor ARC by Ras in human cancers. J Biol Chem, 2010. 285: 19235-19245. PMID: 20392691 PMCID: PMC2885202 Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol, 2010. 72: 19-44. PMID: 20148665

Zaiman A, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozhammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT. A critical role for the protein apoptosis repressor with caspase recruitment domain (ARC) in hypoxia-induced pulmonary hypertension. Circulation, 2011. 124: 2533-2542. PMID: 22082675 Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW, Kitsis RN. Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer Res, 2011. 71: 7705-7715. PMID: 22037876 PMCID: PMC3245742

Whelan, RS, Konstantinidis K, Wei A-C, Chun Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn II GW, O’Rourke B, Kitsis RN. Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci (USA), 2012. 109: 6566-6571. PMID: 22493254 PMCID: PMC3340068 Kontantinidis K, Kitsis RN. Escaped DNA inflames the heart. Nature, 2012. 485: 179-180. PMID: 22575953

McKimpson WM, Weinberger J, Czerski L, Zheng M, Crow MT, Pessin JE, Chua Jr SC, Kitsis RN. The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote ?-cell Survival. Diabetes, 2013. 62: 183-193. PMID: 22933109 PMCID: PMC3526036

Kung G, Dai P, Deng L, Kitsis RN. A novel role for the apoptosis inhibitor ARC in suppressing TNF?-induced regulated necrosis. Cell Death Differ, 2014. 21: 634-644. PMID: 24440909
Dr. Kitsis received his Bachelor’s degree in Chemistry with highest honors from Harvard University and his M.D. from the University of California, San Francisco. He completed his internal medicine residency training at Massachusetts General Hospital and the Boston VA Medical Center, and cardiology fellowship at Montefiore Medical Center. Following this, he did a postdoctoral research fellowship at Albert Einstein College of Medicine.
Richard N. Kitsis, MD, Attending Cardiologist, Montefiore, Cardiology (Heart)