Surgeon-in-Chief
Samuel I. Belkin Chair
Professor and Chairman, Department of Cardiovascular and Thoracic Surgery
Professor and Chairman, Department of Surgery
Co-Director, Montefiore-Einstein Heart Center
Awards and Honors
Harvard University Magna Cum Laude
Dartmouth Leopold Schepp Scholar Medical School
Columbia University Blakemore Research Prize
College of Physicians and Surgeons 1985; 1986; 1987
President Hipolito Mejia La Orden Heraldica de Cristobal Colon
Dominican Republic (The Order of Christopher Columbus)
Presented by the President of the Dominican Republic
(Awarded for Heart Care International's humanitarian heart surgery missions)
March 17, 2003
ABC World News Person of the Week - With Peter Jennings
Tonight February 18, 1995
Columbia University Claire Lucille Pace Humanitarian Award
College of Physicians and Surgeons May 13, 1996
Erasmus Foundation Honorary President
Brussels, Belgium Erasmus Foundation
Chateau de la Hulpe
June 7, 2000
Castle, Connolly Guide America's Top Doctors
Woodward/White, Inc. The Best Doctors in America, The Best Doctors in New York
Castle, Connolly Guide The Best Doctors in the North East
Best Surgical Presentation OMEN - National Organization for Continuing Medical Education
2001-2002 "Live Surgery: Minimally Invasive Mitral Valve Repair"
Best Team Award OMEN - National Organization for Continuing Medical Education
1999 "New Approaches to Cardio Revascularization"
Best Team Award OMEN - National Organization for Continuing Medical Education
1998 "Pathology and Repair of the Mitral Valve"
Who's Who in the World - Marquis
Who's Who Marquis Medicine and Healthcare
Who's Who Strathmore's
Who's Who in Science and Engineering
Who's Who in America
Clinical Trials
Clinical Evaluation of the HeartMate II Axial Flow Device as a Bridge to Transplant. (Multicenter, FDA Clinical Trial, Thoratec Corporation)
Co-Investigator
2005-present
Randomized Evaluation of the HeartMate II Axial Flow Device versus the HeartMate XVE as Destination Therapy (Multicenter, FDA Clinical Trial, Thoratec Corporation)
Co-Investigator
2005-present
Pivotal Trial of the MicroMed DeBakey Axial Flow Device as a Bridge to Transplantation (Multicenter, FDA Clinical Trial, MicroMed)
Co-Investigator
2005-present
Randomized Evaluation of the MicroMed DeBakey VAD as Permanent Therapy. (Multicenter, FDA Clinical Trial, MicroMed)
Co-Investigator
2005-present
Phase I Study of Intra-Cardiac Injection of Autologous Myoblasts into Transmural Myocardial Scar (Multicenter, FDA Clinical Trial, Diacrin, Inc.)
Principal Investigator
2003 - 2005
Autologous Myoblast Transplantation for the Treatment of Infarcted Myocardium - A Pilot Study (Multicenter, FDA Clinical Trial, Diacrin, Inc.)
Principal Investigator
2001 - 2002
Surgical Treatment for Ischemic Heart (STICH) Failure Trial
(Multicenter, NHBLI Clinical Trial)
Principal Investigator
2002 - Present
Mitral Valve Repair Using the da Vinci Robotic Surgical System (Multicenter, FDA Clinical Trial, Intuitive Surgical, Inc.)
Principal Investigator
2001 - 2002
Robotic Internal Mammary Artery (IMA) MIS Mobilization (Single site, FDA Clinical Trial, Intuitive Surgical, Inc.)
Principal Investigator
1998
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Ex-Vivo Treatment with CGT003 of Coronary Vein Grafts in Patients Undergoing Coronary Artery Bypass Procedures (Multicenter, FDA Clinical Trial, Corgentech, Inc.)
Co-Investigator
2003 - 2005
Clinical Evaluation of the Thoracatec Implantable Ventricular Assist Device (Multicenter, FDA Clinical Trial, Thoratec Corporation)
Principal Investigator
2002 - 2005
Left Ventricular Mass Regression on-X Prosthetic Heart Valve (Single site, Medical Carbon Research Institute, LLC)
Principal Investigator
2001 - 2004
Sutured-Clip LITA/LIMA to LAD Anastamosis Study Investigational Plan/Protocol (Multicenter, Coalescent Surgical, Inc.)
Co-Investigator
2000 - 2002
Evaluation of Short Term Use of the AB-180 Percutaneous Transseptal Ventricular Assist (PTVA) System for Cardiogenic Shock (Mulicenter, FDA Clinical Trial, CardiacAssist, Inc.)
Principal Investigator
2000 - 2002
Heartpak Portable Pneumatic Driver Clinical Study (Multicenter, FDA Clinical Study, Thoratec Corporation)
Principal Investigator
2000 - 2002
AB - 180 Circulatory Support System for the Treatment of Reversible Heart Failure (Multicenter, FDA Clinical Trial, CardiacAssist Technologies)
Co-Investigator
1999 - 2001
Multicenter, Randomized, Placebo Controlled Trial of Simulect in De Novo Heart Transplant Recipients Treated in Combination with Neoral, Cellcept, and Steroids for the Prevention of Acute Rejection Episodes (Multicenter, FDA Clinical Trial, Novartis Pharmaceuticals Corporation)
Principal Investigator
1999 - 2000
TMR and CABG vs. CABG Alone (Multicenter, FDA Clinical Trial, Eclipse Surgical Technologies)
Principal Investigator
1999 - 2001
An Observational, Prospective Study of the SJM Tailor Annuloplasty Ring (Multicenter, St. Jude Medical, Inc.)
Principal Investigator
1998 - 2000
TMR System - Adjunct to CABG (Multicenter, FDA Clinical Trial, CardioGenesis Corporation)
Principal Investigator
1998 - 1999
PerFCT: PERMA-Flow CABG Trial, Phase II (Multicenter, Possis Medical)
Principal Investigator
1996 - 1999
An Open Label Study of Mycophenolate Mofetil for Treatment of Refractory A Cellular Allograft Rejection in Solid Organ Transplant Recipients
Principal Investigator
1995
North American CarboMedics Valve Study Group
Principal Investigator
1994
Journal Articles
1. Michler RE, McManus RP, Sadeghi AM, Smith CR, Marboe CC, Thomas WG, Hardy MA, Reemtsma K, Rose EA. Prolonged primate cardiac xenograft survival with cyclosporine. Surg Forum 1985;36:359?60.
2. Michler RE, McManus RP, Smith CR, Sadeghi AM, Rose EA. Technique for primate heterotopic cardiac xenotransplantation. J Med Primatol 1985;14:357-62.
3. Kurlansky PA, Dresdale AR, Pierson R, McManus RP, Michler RE, Sachs HT, Thomas WG, Lau H, Hardy MA, Marboe C, Reemtsma K, Rose EA. Prolongation of canine cardiac allograft survival using donor?specific buffy coat pretransfusion. Transplantation 1986;42:98?101.
4. Michler RE, Smith CR, Drusin RE, Reison DS, Hickey T, Lamb J, Reemtsma K, Rose EA. Reversal of cardiac transplant rejection without massive immunosuppression. Circulation 1986;74:68?71.
5. Sadeghi AM, Rose EA, Michler RE, Smith CR, Baumgartner WA. A simplified method for the occlusion of the venae cavae during cardiopulmonary bypass. Ann Thor Surg 1986;41:678.
6. Thomas WG, Sadeghi AM, Kurlansky PA, Michler RE, Smith CR, Reemtsma K, Rose EA. Postoperative bone marrow injections with cyclosporine or antithymocyte globulin in rat cardiac allografts. Transplantation 1986;42:441?2.
7. Kurlansky PA, Sadeghi AM, Michler RE, Smith CR, Marboe CC, Thomas WG, Coppey LJ, Reemtsma K, Rose EA. Prolonged cardiac xenograft survival: A favorable comparison with allografts in primates. Curr Surg 1986;43:413?5.
8. Sadeghi AM, Weber CJ, Chabot J, Kurlansky PA, Michler RE, Rose EA, Reemtsma, K, Smith CR. Hemorrhagic pancreatitis following heart lung preservation in primates. Surg Forum 1986;37:257?8.
9. Kurlansky PA, Sadeghi AM, Michler RE, Coppey, LJ, Re LP, Thomas WG, Smith CR, Reemtsma K, Rose EA. The role of the carrier solution in cyclosporine pharmakokinetics in the baboon. J Heart Transplant 1986;5:312?6.
10. Weber CJ, Hardy MA, Rivera S, Bailey?Braxton D, Michler RE, Thomas WG, Chabot J, Pi Sunyer FX, Wood M, Reemtsma K. Diabetic mouse bioassay for functional and immunologic human and primate islet xenograft survival. Transplant Proc 1986;18:823?8.
11. Michler RE, McManus RP, Sadeghi AM, Kurlansky PA, Smith CR, Marboe CC, Thomas WG, Reemtsma K, Rose EA. Pretransplant blood transfusion in a primate cardiac xenograft model. Curr Surg 1987;44:42?5.
12. Michler RE, McManus RP, Smith CR, Sadeghi AM, Marboe CC, Reemtsma K, Rose EA. Prolongation of primate cardiac xenograft survival with cyclosporine. Transplantation 1987;44:632?6.
13. Addonizio LJ, Michler RE, Marboe CC, Esser PR, Johnson LL, Seldin DW, Gersony WM, Alderson PO, Rose EA, Cannon PJ. Imaging of cardiac allograft rejection in dogs using Indium?111 monoclonal antimyosin (Fab). J Am Coll Cardiol 1987;9:555?64.
14. Kurlansky PA, Sadeghi AM, Michler RE, Smith CR, Marboe CC, Thomas WG, Coppey LJ, Reemtsma K, Rose EA. Comparable survival of intra-species and cross?species primate cardiac transplants. Transplant Proc 1987;19:1067?71.
15. Sadeghi AM, Robbins RC, Smith CR, Kurlansky PA, Michler RE, Thomas WG, Marboe CC, Reemtsma K, Rose EA. Cardiac xenograft survival in baboons treated with cyclosporine in combination with conventional immunosupression. Transplant Proc 1987;19:1149?52.
16. Sadeghi AM, Robbins, RC, Smith CR, Kurlansky PA, Michler RE, Reemtsma K, Rose EA. Cardiac xenotransplantation in primates. J Thor Cardiovasc Surg 1987;93:809?14.
17. Socha WW, Marboe CC, Michler RE, Rose EA, Moor?Jankowski J. Primate animal model for the study of ABO incompatibility in organ transplantation. Transplant Proc 1987;19:4448?55.
18. Michler RE, Marboe CC, Socha WW, Moor?Jankowski J, Reemtsma K, Rose EA. Simian?type blood group antigens in non?human cardiac xenotransplantation. Transplant Proc 1987;19:4456?62.
19. Reemtsma K, Pierson RN, Marboe CC, Michler RE, Smith CR, Rose EA, Fenoglio J. Will atherosclerosis limit clinical xenografting? Transplant Proc 1987;19:108?18.
20. Michler RE, Socha WW, Marboe CC, Smith CR, Reemtsma K, Moor?Jankowski J, Rose EA. Macaque to baboon cardiac transplantation: Model of choice for xenotransplantation in man. Transplant Proc 1988;20:327?8.
21. Dangman KH, Dresdner KP, Michler RE. Transmembrane action potentials and intracellular K+ activity of baboon cardiac tissues. Cardiovasc Res 1988;22:204?12.
22. Rose EA, Michler RE, Smith CR, McManus RP, Sadeghi AM, Drusin RE, Reemtsma K. Present status of human cardiac allografts and prospects for xenografts. ASAIO 1988;11:19?23.
23. Michler RE, Rose EA. Pediatric heart and heart?lung transplantation. Ann Thor Surg 1991;52:708-9.
24. Frank RA, Sanchez JA, Addonizio LJ, Hsu DT, Rose EA, Michler RE. OKT3 Induction therapy increases early infections and does not reduce early rejections in pediatric heart transplantation. J Heart Lung Transplant 1991;10:161.
25. Michler RE, Barr ML, Schenkel FA, Ho E, Reid E, Suciu?Foca N, Rose EA. Impact of a positive cross?match on rejection and survival following orthotopic heart transplantation. Circulation 1992;86:628.
26. Wechsler M, Giardina EG, Sciacca R, Barr M, Michler RE, Marboe CC, Catanese K, Schenkel F, Smith CR, Rose EA. Increased mortality from mismatched cytomegalovirus status in females undergoing cardiac transplant. Circulation 1992;86:358.
27. Jeevanandum V, Barr ML, Auteri JS, Sanchez JA, Fong J, Schenkel FA, Marboe CC, Michler RE, Smith CR, Rose EA. University of Wisconsin solution versus crystalloid cardioplegia for human donor heart preservation. J Thor Cardiovasc Surg 1992;103:194?9.
28. Ensley RD, Hunt S, Taylor DO, Renlund DG, Menlove RL, Karwande SV, O'Connell JB, Barr ML, Michler RE, Copeland JG, Miller LW. Predictors of survival after repeat heart transplantation. J Heart Lung Transplant 1992;11:142?58.
29. Michler RE, Rose EA. Xenograft cardiac transplantation: Will it ever be a clinical reality? Coronary Artery Disease 1992;3:825?30.
30. Jeevanandum V, Bielefeld MR, Auteri JS, Sanchez JA, Schenkel FA, Michler RE, Smith CR, Livelli F, Jr., Bigger JT, Jr., Rose EA, Spotnitz HM. The implantable defibrillator: An electronic bridge to cardiac transplantation. Circulation 1992;86:276?9.
31. Michler RE, McLauglin MJ, Chen JM, Geimen R, Schenkel BS, Smith CR, Barr ML, Rose EA. Clinical experience with cardiac retransplantation. J Thor Cardiovasc Surg 1993;106:622-31.
32. Chen JM, Barr ML, Chadburn A, Frizzera G, Schenkel FA, Sciacca RR, Reison DS, Addonizio LJ, Rose EA, Knowles DM, Michler RE. Management of lymphoproliferative disorders after cardiac transplantation. Ann Thor Surg 1993;56:527?38.
33. Michler RE, Chowdhury N, Cai B, Yang X, Bredt J, Marboe CC, Cannon PJ. Cardiac allograft rejection induces myocardial nitric oxide synthase. Circulation 1993;88:383.
34. Oz MC, Rose EA, Michler RE, Spotnitz HN, Smith CR, Liao H, Stem DM, Pinsky DJ. Coronary vascular endothelium may release contents of Weibel?Pallade bodies but does not shed membrane proteins during cardiac surgery. Circulation 1993;88:247.
35. Pinsky DJ, Chowdhury N, Oz MC, Liao H, Yano 0, Nowygrod R, Michler RE, Stern DM. Cyclic nucleotides enhance lung preservation in an orthotopic rat lung transplant model. Circulation 1993;88:40.
36. Sistino JJ, Michler RE, Mongero LB. Laboratory evaluation of a low prime closed?circuit cardiopulmonary bypass system. J Extra?Corp Tech 1993;24:116?9.
37. Sistino JJ, Michler RE, Schwartz A, Marboe CC, Mongero LB, Geiman R, Kwiatkowski PA. Safety of heparin?coated circuits in primates during deep hypothermic cardiopulmonary bypass. J Extra?Corp Tech 1993;25:15?21.
38. Chen JM, Michler RE. Heart xenotransplantation: Lessons learned and future prospects. J Heart Lung Transplant 1993;12:869?75.
39. Oz MC, Pinsky DJ, Koga S, Liao H, Marboe CC, Han D, Kline R, Jeevanandam V, Williams M, Morales A, Popilskis S, Nowygrod R, Stern DM, Rose EA, Michler RE. Novel preservation solution permits 24 hour preservation in rat and baboon cardiac transplant models. Circulation 1993;88:292?7.
40. Michler RE, Edwards NM, Hsu D, Bernstein D, Fricker FJ, Miller J, Copeland J, Kaye M, Addonizio L. Pediatric retransplantation. J Heart Lung Transplant 1993;12:319?27.
41. Michler RE, Chisholm P, Hochman PS, Kaplon RJ, Berger CL, Majeau GR, Miller GT, Williams CA, Kwiatkowski PA, Mitra A, Xu H, Meier W, Wallner BP, Marboe CC. Prolongation of primate cardiac allograft survival by short course monotherapy with an LFA?3?IgG1 fusion protein. Surg Forum 1993;44:409?11.
42. Garrett TJ, Chadbum A, Barr ML, Drusin RE, Chen JM, Schulman LL, Smith CR, Reison DS, Rose EA, Michler RE, Knowles DM. Posttransplantation lymphoproliferative disorders treated with Cyclophospamide-Doxorubicin-Vincristine-Prednisone chemotherapy. Cancer 1993;72:2782?5.
43. Hsu DT, Garofano RP, Douglas JM, Michler RE, Quaegebeur JM, Gersony WM, Addonizio LJ. Exercise performance after pediatric heart transplantation. Circulation 1993;88:238?42.
44. Addonizio LJ, Hsu DT, Douglas JF, Kichuk MR, Michler RE, Quaegebeur JM, Smith CR, Rose EA. Decreasing incidence of coronary disease in pediatric cardiac transplant recipients using increased immunosuppression. Circulation 1993;88:224?9.
45. Sistino JJ, Mongero LB, Michler RE, Quaegebeur JM. Dilutional effects of cardiopulmonary bypass in patients less than 15 kilograms using low prime circuits. Proc Am Acad Card Perf 1993;14:98?103.
46. Schwartz AE, Michler RE, Sistino JJ, Young WL. Effect of deep hypothermic total circulatory arrest on CBF and metabolism in baboons. Anesth Analg 1993;76:379.
47. Chen JM, Weinberg AD, Rose EA, Mancini DM, Reemtsma K, Michler RE. Multivariable analysis of factors affecting waiting time to heart transplantation. Circulation 1994;90:152.
48. Chowdhury NC, Naka Y, Pinsky D, Yano OJ, Smith CR, Rose EA, Stern DM, Michler RE, Oz MC. Novel technique of orthotopic lung transplantation in rats in which survival and hemodynamic assessment can be measured independent of the native lung. Surg Forum 1994;45:268?70.
49. Oz MC, Naka Y, Liao H, Maloney C, Seldomridge A, Michler RE, Smith CR, Rose EA, Pinsky DJ. Coronary sinus interleukin?8 and myoglobin are elevated following human heart transplantation. Circulation 1994;90:361.
50. Naka Y, Chowdhury NC, Liao H, Michler RE, Stern DM, Pinsky DJ. Elevation of intracellular cAMP by a phosphodiesterase inhibitor of cAMP analogs improves vascular function in orthotopic rat lung transplants. Circulation 1994;90:151.
51. Naka Y, Chowdhury NC, Michler RE, Liao H, Stern DM, Pinsky DJ. Deleterious effects of P-selectin? dependent neutrophil recruitment on graft survival and function in an orthotopic rat lung transplant model. Circulation 1994;90:361.
52. Kichuk M, Seyedi N, Marboe CC, Addonizio L, Michler RE, Nasjletti A, Hintze T. Kinins mediate nitric oxide production in response to alpha?adrenergic stimulation in microvessels from the failing human heart. Circulation 1994;90:295.
53. Michler RE, Chen JM, Quaegebeur JM. Novel technique for extending the use of allografts in cardiac operations. Ann Thor Surg 1994;57:83?7.
54. Smith CR, Mongero L, DeRosa CM, Michler RE, Oz M. Safety of Aprotinin in profound hypothermia and circulatory arrest. Ann Thor Surg 1994;58:606?8.
55. Yang X, Chowdhury N, Cai B, Brett J, Marboe C, Sciacca RR, Michler RE, Cannon PJ. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Inves 1994:714?21.
56. Kaplon RJ, Platt JL, Xu H, Kwiatkowski PA, Edwards NM, Michler RE. Prolonged survival of pig cardiac xenografts in unmodified newborn baboons. Transplant Proc 1994;26:1072.
57. Michler RE, Chen JM. Cardiac xenotransplantation: A therapy whose time has come. Xenotransplantation 1994;2:1?3.
58. Xu H, Edwards N, Chen JM, Dong X, Kaplon RJ, Kwiatkowski PA, Michler RE. Identification and functional analysis of human natural anti?pig xenoantibodies. Transplant Proc 1994;26:1365?8.
59. Pinsky DJ, Naka Y, Chowdhury NC, Liao H, Oz MC, Michler RE, Kubaszewski E, Malinski T, Stern DM. The nitric oxide/cyclic GMP pathway in organ transplantation: Critical role in successful lung preservation. Proc Natl Acad Sci USA 1994;91:12086?90.
60. Leibowitz DW, Smith CR, Michler RE, Ginsburg M, Schulman L, McGregor CC, LiMandri G, Weslow RG, DiTullio MR, Homma S. Incidence of pulmonary vein complications after lung transplantation: A prospective transesophageal echocardiographic study. J Am Coll Cardiol 1994;24:671?5.
61. Michler RE, Chen JM, Quaegebeur JM. Allografts for outflow tract reconstruction in pediatric patients (Reply). Ann Thor Surg 1994;58:915.
62. Schwartz AE, Kaplon RJ, Young WL, Sistino JJ, Kwiatkowski PA, Michler RE. Cerebral blood flow during low?flow hypothermic cardiopulmonary bypass in baboons. Anesthesiology 1994;81:959?64.
63. Sandhu AA, Schwartz AE, Stone JG, Fink AD, Olewine RG, Kaplon RJ, Adams DC, Jonassen AE, Kwiatkowski P, Michler RE. Hemodynamic stability during selective brain cooling. Circulation 1994;90:201.
64. Xu H, Kwiatkowski PA, Chen JM, Kaplon RJ, Edwards NM, Dong X, Berger C, Michler RE. Abrogation of baboon natural xenoantibody to pig splenocytes by DL?penicillamine. Transplantation 1994;58:1299?1303.
65. Kaplon RJ, Platt JL, Kwiatkowski PA, Edwards NM, Xu H, Shah AS, Michler RE. Absence of hyperacute rejection in pig?to?primate orthotopic pulmonary xenografts. Transplantation 1995;59:410?16.
66. Slater JP, Amirhamzeh MR,, Yano OJ, Shah AS, Starr JP, Kaplon RJ, Burfeind W, Pepino P, Michler RE, Rose EA, Smith CR, Spotnitz HM, Oz MC. Discriminating between preservation and reperfusion injury in human cardiac allografts using heart weight and left ventricular mass. Circulation 1995;92:223?7.
67. Kaplon RJ, Michler RE, Xu X, Kwiatkowski PA, Edwards NM, Platt JL. Absence of hyperacute rejection in newborn pig?to?baboon cardiac xenografts. Transplantation 1995;59:1?6.
68. Masroor S, Schroeder TJ, Michler RE, Alexander JW, First MR. Monoclonal antibodies in organ transplantation: An overview. Transplant Immunol 1994;2:176?89.
69. Naka Y, Chowdhury N, Oz M, Michler RE, Yano O, Smith CR, Stem D, Pinsky D. Nitroglycerin maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model. J Thor Cardiovasc Surg 1995;109:206?11.
70. Hsu DT, Quaegebeur JM, Michler RE, Smith CR, Rose EA, Kichuk MR, Gersony WM, Douglas JF, Addonizio LJ. Heart transplantation in children with congenital heart disease. J Am Coll Cardiol 1995;26:743?9.
71. Goldstein DJ, Oz MC, Rose EA, Fisher P, Michler RE. Experience with heart transplantation for cardiac tumors. J Heart Lung Transplant 1995;14:382?6.
72. Naka Y, Chowdhury NC, Liao H, Oz MC, Michler RE, Pinsky DJ. Enhanced preservation of orthotopically transplanted rat lungs by nitroglycerin but not hydralazine: Requirement for graft vascular homeostasis beyond harvest vasodilation. Circ Res 1995;76:900?6.
73. Michler RE, Sandhu AA. A novel approach for orthotopic heart transplantation in visceroatrial situs inversus. Ann Thor Surg 1995;60:194?7.
74. Xu H, Edwards NM, Chen JM, Kwiatkowski PA, Michler RE. Newborn baboon serum lacks natural anti?pig xenoantibody. Transplantation 1995;59:1189?94.
75. Shah AS, Michler RE, Downey RJ, Leibowitz DW, Homma S, Smith CR. Management strategies for pulmonary vein thrombosis following single lung transplantation. J Cardiovasc Surg 1995;10:169?78.
76. Shah AS, Michler RE. Successful heart transplantation for acquired pulmonary artery atresia. Ann Thor Surg 1995;59:1557?9.
77. Chadburn A, Cesarman E, Liu YF, Addonizio LJ, Hsu D, Michler RE, Knowles DM. Molecular genetic analysis demonstrates that multiple posttransplantation lymphoproliferative disorders occurring in one anatomic site in a single patient represent distinct primary lymphoid neoplasms. Cancer 1995;75:2747?56.
78. Leibowitz DW. Michler RE, Smith CR, Schulman LL, McGregor CC, Di Tullio MR, Homma S. Transesophageal echocardiographic assessment of the pulmonary venous anastomoses after lung transplantation. Circulation 1995;92:594.
79. Ravalli S, Marboe CC, D'Agati VD, Michler RE, Sigal E, Cannon PJ. Immunohistochemical demonstration of 15?lipoxygenase in transplant?associated coronary artery disease. Arterioscler Thromb Vasc Biol 1995;15:340?8.
80. Xu H, Edwards NM, Chen JM, Dong X, Michler RE. Natural anti?pig xenoantibody is absent in neonatal human serum. J Heart Lung Transplant 1995;749?54.
81. Xu H, Edwards NM, Chen JM, Dong X, Michler RE. Age?related development of human anti?pig xenoantibody. J Thor Cardiovasc Surg 1995;110:1023?9.
82. Stone JG, Schwartz AE, Fink AD, Sandhu AA, Adams DC, Wald A, Mongero LB, Michler RE. Brain temperature monitoring during induced hypothermia. Anesthesiology 1995;83:173.
83. Schwartz AS, Sandhu AA, Kaplon RJ, Young WL, Jonassen AE, Adams DC, Edwards NM, Sistino JJ, Kwiatkowski P, Michler RE. Cerebral blood flow is determined by arterial pressure and not cardiopulmonary bypass flow rate. Ann Thor Surg 1995;60:165?70.
84. Suciu?Foca N, Liu Z, Harris E, Reed EF, Cohen DJ, Bernstein JA, Benvenisty AI, Mancini D, Michler RE, Rose EA, Reemtsma K, Hardy M. Indirect recognition of native HLA alloantigens and B cell help. Transplant Proc 1995;27:455?6.
85. Naka Y, Chowdhury NC, Oz MC, Smith CR, Yano OJ, Michler RE, Stern DM, Pinsky DJ. Nitroglycerine maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model. J Cardiov Surg 1995;109:1-6.
86. Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 1995;85:552?65.
87. Frank D, Cesarman E, Fang Liu Y, Michler RE, Knowles DM. Posttransplantation lymphoproliferative disorders frequently contain type A and not type B Epstein?Barr virus. Blood 1995;85:1396?403.
88. Oz MC, Liao H, Naka Y, Seldomridge A, Becker D, Michler RE, Smith CR, Rose EA, Stern DM, Pinsky DJ. Ischemia?induced interleukin?8 release after human heart transplantation. Circulation 1995;92:428?32.
89. Goldstein DJ, Seldomridge A, Addonizio L, Rose EA, Oz MC, Michler RE. Orthotopic heart transplantation in patients with treated malignancies. Am J Cardiol 1995;75:968?71.
90. Naka Y, Roy DK, Smerling AJ, Michler RE, Smith CR, Stern DM, Oz MC, Pinsky DJ. Inhaled nitric oxide fails to confer the pulmonary protection provided by distal stimulation of the nitric oxide pathway at the level of cGMP. J Thor Cardiovasc Surg 1995;110:1434?41.
91. Sandhu AA, Schwartz AE, Stone JG, Finck D, Kwiatkowski PA, Mongero LB, Michler RE. Selective brain cooling. Surg Forum 1995;46:292?4.
92. Mohazzab?H K, Zhang X, Kichuk M, Michler RE, Kaley G, Wolin M. Potential sites and changes of superoxide anion production in failing and non?failing explanted human cardiac myocytes. Circulation 1995;92:32.
93. Michler, RE, Szabolcs M, Roy D, Aji W, Wang Y, Yang X, Sciacca RR, Cannon PJ. Apoptosis of cardiac myocytes parallels the induction of nitric oxide synthase (INOS) during cardiac allograft rejection. Circulation 1995;92:123.
94. Michler RE, Sandhu AA, Young WL, Schwartz AE. Low flow cardiopulmonary bypass: Low-flow cardiopulmonary bypass: Importance of blood pressure in maintaining cerebral blood flow. Ann Thor Surg 1995;60:525?8.
95. Goldstein DJ, DeRosa CM, Mongero LB, Weinberg AD, Michler RE, Rose EA, Oz MC, Smith CR. Safety and efficacy of aprotinin under deep hypothermia and circulatory arrest. J Thor Cardiovasc Surg 1995;110:1615?22.
96. Goldstein DJ, Oz MC, Michler RE. Radical excisional therapy and total cardiac transplantation for recurrent atrial myxoma. Ann Thor Surg 1995;60:1105?7.
97. Shah AS, Smerling AJ, Quaegebeur J, Michler RE. Nitric oxide treatment for pulmonary hypertension after neonatal cardiac surgery. Ann Thor Surg 1995;60:1791?3.
98. Ashton RC, Oz MC, Michler RE, Catanese KA, Hsu DT, Addonizio LJ, Quaegebeur JM. Left ventricular assist device options in pediatric patients. ASAIO J 1995;41:277?80.
99. Ashton RC, Whitworth GC, Seldomridge A, Shapiro PS, Michler RE, Smith CR, Rose EA, Fisher S, Oz MC. The effects of self?hypnosis on quality of life following coronary artery bypass surgery: A prospective, randomized trial. J Altern Complement Med 1995;1:285-90.
100. Fisher PE, Suciu?Foca N, Ho E, Michler RE, Rose EA, Mancini DM. Additive value of immunologic monitoring to histologic grading of heart allograft biopsies: Implications for therapy. J Heart Lung Transplant 1995;14:1156?61.
101. Michler RE, O'Hair DP, Xu H, Shah AS. Newborn baboon immunity: Lessons in cross species transplantation. Ann Thor Surg 1995;60:582-4.
102. Cai B, Roy D, Sciacca R, Michler RE, Cannon PJ. Effects of immunosuppressive therapy on expression of inducible nitric oxide synthase during cardiac allograft rejection. Int J Cardiol 1995;50:243?51.
103. Neethling F, Cooper DKC, Xu H, Michler RE. Newborn baboon serum anti?alphagalactosyl antibody levels and cytotoxicity to cultured pig kidney (PK 15) cells. Transplantation 1995;60:520?1.
104. Chadburn A, Suciu?Foca N, Cesarman E, Reed E, Michler RE, Knowles DM. Posttransplantation lymphoproliferative disorders (PT?LPDs) arising in solid organ transplant recipients are usually of recipient origin. Am J Pathology 1995;147:1862?70.
105. Goldstein DJ, Williams DL, Oz MC, Weinberg AD, Rose EA, Michler RE. De Novo solid malignancies following cardiac transplantation. Ann Thor Surg 1995;60:1783?9.
106. Khan S, Ravalli S, Szabolcs M, D'Agati VD, Michler RE, Cannon PJ. T-lymphocyte accumulation and proliferation in transplant and native atherosclerosis. Circulation 1995;92:497.
107. Schulman LL, Shreeniwas R, McGregor CC, Ginsburg ME, Michler RE, Oz MC, Fisher PE, Smith CR. Bronchial anastomotic complications after lung transplantation. J Bronchology 1996;3:271-9.
108. Schwartz AE, Stone JG, Finck AD, Sandhu AA, Mongero LB, Adams DC, Jonassen AE, Young WL, Michler RE. Isolated cerebral hypothermia by single carotid artery perfusion of extracorporeally cooled blood in baboons. Neurosurgery 1996;39:577-82.
109. Chen JM, Levin HR, Rose EA, Addonizio LJ, Landry DW, Sistino JJ, Michler RE, Oz MC. Experience with right ventricular assist devices for perioperative right sided circulatory failure. Ann Thor Surg 1996;61:305?10.
110. Kichuk MR, Seyedi N, Zhang X, Marboe CC, Michler RE, Addonizio LJ, Kaley G, Hintze T. Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation. Circulation 1996;94:44-51.
111. Ravalli S, Szabolcs M, Albala A, Michler RE, Cannon PJ. Increased immunoreactive endothelin-1 in human transplant coronary artery disease. Circulation 1996;94:2096-102.
112. Chen JM, Weinberg AD, Rose EA, Thompson SM, Mancini DM, Ellison JP, Reemtsma K, Michler RE. Multivariate analysis of factors affecting waiting time to heart transplantation. Ann Thor Surg 1996;61:570?5.
113. Xu H, Oluwole SF, Edwards NM, Chen JM, Naka Y, Kim E, Michler RE. In vitro evaluation of neonatal human immunity against the pig. J Thor Cardiovasc Surg 1996;111:920-9.
114. Shane E, Rivas M, Staron RB, Silverberg SJ, Seibel MJ, Kulper J, Mancini DM, Addesso V, Michler RE, Factor?Litvak P. Fracture after cardiac transplantation: A prospective longitudinal study. J Clin Endocrinol Metab 1996;81:1740?6.
115. Kaplon RJ, Hochman PS, Michler RE, Kwiatkowski PA, Edwards NM, Berger CL, Xu H, Meier W, Wallner BP, Chisholm P, Marboe CC. Short course single agent therapy with an LFA?3-IgG1 fusion protein prolongs primate cardiac allograft survival. Transplantation 1996;61:356-63.
116. Michler RE, Xu H, O'Hair DP, Shah A, Kwiatkowski PA, Minanov O, Itescu S. Newborn discordant cardiac xenotransplantation in primates: A model of natural antibody depletion. Transplant Proc 1996;28:651?2.
117. Shah AS, Itescu S, O'Hair DP, Tugulea S, Kwiatkowski PA, Liu Z, Platt JL, Rose EA, Suciu-Foca N, Michler RE. Importance of cell?mediated immune responses in rejection of concordant heart xenografts in primates. Transplant Proc 1996;28:775-6.
118. Schwartz AE, Stone JG, Finck AD, Sandhu AA, Adams DC, Young WL, Mongero LB, Michler RE. Hypothermia alters the global distribution of cerebral blood flow in baboons. Anesth Analg 1996;82:398.
119. Szabolcs M, Michler RE, Yang X, Aji W, Roy D, Athan E, Sciacca RR, Minanov O, Cannon PJ. Apoptosis of cardiac myocytes during cardiac allograft rejection: Relation to induction of nitric oxide synthase. Circulation 1996;94:1665-73.
120. Yang X, Szabolcs M, Athan E, Minanov OP, Sciacca RR, Bianchi M, Ulrich P, Tracey KJ, Michler RE, Cannon PJ. CNI-1493 reduces apoptosis and necrosis and prolongs survival during rat cardiac allograft rejection. Circulation 1996;94:54.
121. Michler RE. Xenotransplantation: Risks, clinical potential, and future prospects. Emerg Infect Dis 1996;2:64?70.
122. Minanov OP, Itescu S, Michler RE. Recent advances and potential for clinical use of xenotransplantation. Curr Opin Cardiol 1996;11:214-20.
123. Goldstein DJ, Austin JHM, Zuech N, Williams DL, Stoopler MB, Michler RE, Schulman LL. Carcinoma of the lung after heart transplantation. Transplantation 1996;62:772-5.
124. Shwartz AE, Minanov O, Stone JG, Adams DC, Sandhu AA, Pearson ME, Kwiatkowski P, Young WL, Michler RE. Phenylephrine increases cerebral blood flow during low?flow hypothermic cardiopulmonary bypass in baboons. Anesthesiology 1996;85:380-4.
125. Shwartz AE, Stone JG, Pile?Spellman J, Finck AD, Sandhu AA, Mongero LB, Michler RE. Selective cerebral hypothermia by transfemoral internal carotid artery catheterization. Radiology 1996;201:571-2.
126. Michler RE. Xenotransplantation: Risks and prospects. Xenotransplantation 1996;4:1-4.
127. Liu Z, Colovai A, Tugulea S, Reed EF, Fisher PE, Mancini D, Rose EA, Cortesini R, Michler RE, Sucio?Foca N. Indirect recognition of donor HLA?DR peptides in organ allograft rejection. J Clin Invest 1996;98:1150-7.
128. Minanov OP, Ma N, Yang X, Ulrich P, Tracey KJ, Cannon PJ, Michler RE. An inhibitor of macrophage proinflammatory cytokines and nitric oxide production (CNI-1493) prolongs graft life in transplanted rat hearts. Surg Forum 1996;47:418-20.
129. Michler RE, Shah AS, Itescu S, O'Hair DP, Tugulea S, Kwiatkowski PW, Liu Z, Platt JL, Rose EA, Suciu-Foca N. The influence of concordant xenografts on the humoral and cell-mediated immune responses to subsequent allografts in primates. J Thor Cardiovasc Surg 1996;112:1002-9.
130. Shah AS, Itescu S, O'Hair DP, Tugulea S, Kwiatkowski P, Liu Z, Platt JL, Rose EA, Suciu-Foca N, Michler RE. Immunologic studies in primates undergoing concordant xenotransplantation as a bridge to allotransplantation. Transplant Proc 1996;28:745-6.
131. Naka Y, Roy KR, Hui L, Chowdhury NC, Michler RE, Oz MC, Pinsky DJ. CAMP-mediated vascular protection in an orthotopic rat lung transplant model. Circulation 1996;79:773-83.
132. Itescu S, Kwiatkowski P, Wang SF, Blood T, Minanov OP, Michler RE. Circulating human mononuclear cells exhibit augmented lysis of pig endothelium after activation with IL-2. Transplantation 1996;62:1927-33.
133. Itescu S, Weinberg A, Burke E, Levin H, Bosworth BP, Spanier TB, Rose EA, Suciu-Foca N, Oz M, Michler RE. B cell hyperreactivity in recipients of left ventricular assist devices: Association of HLA - DR3 with anti-HLA antibodies and adverse outcome postcardiac transplantation. Circulation 1996;94:293.
134. Itescu S, Wang SF, Kwiatkowski P, Xu H, Minanov OP, Rose S, Michler RE. Effects of human macrophage derived cytokines IL-1 and TNF-alpha on lysis of pig endothelium by IL-2 activated human natural killer cells. Circulation 1996;94:172.
135. Beniaminovitz A, Coromilas J, Oz M, Galantowicz M, Michler RE, Donchez L, Mancini D. Native atrial to orthotopic atrial pacing improves exercise capacity in patients postcardiac transplantation. Circulation 1996;94:112.
136. Aji W, Ravalli S, Szabolcs M, Jiang X, Sciacca RR, Michler RE, Cannon PJ. L?Arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. Circulation 1997;95:430-7.
137. Chen JM, Levin HR, Michler RE, Prusmack CJ, Rose EA, Aaronson KD. Reevaluating the significance of pulmonary hypertension prior to cardiac transplantation: Determination of optimal thresholds and quantification of the effect of reversibility on perioperative mortality. J Thor Cardiovasc Surg 1997;114:627-34.
138. Heyer EJ, Adams DC, Delphin E, McMahon DJ, Steneck S, Oz MC, Michler RE, Rose EA. Cerebral dysfunction after coronary artery bypass grafting with mild or moderate hypothermia. J Thor Cardiovasc Surg 1997;114:270?7.
139. Warshofsky MK, Wasserman HS, Wang W, Teng P, Apfelbaum M, Weinberger JZ, Schwartz A, Michler RE, Mancini DM, Cannon PJ, Rabbani LE. Plasma levels of tissue plasminogen activator and plasminogen inhibitor?1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients.
Am J Cardiol 1997;80:145-9.
140. Minanov OP, Itescu S, Neethling FA, Morgenthau A, Kwiatkowski PA, Cooper DKC, Michler RE. Anti-Gal IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation. Transplantation 1997;63:182-6.
141. Michler RE, Minanov OP, Artrip JH, Itescu S. Immature host for xenotransplantation. World J Surg 1997;21:924?31.
142. Minanov OP, Kwiatkowski PA, Popilskis S, Michler RE. Modified technique for heterotopic heart transplantation in small primates. Ann Thor Surg 1997;63:258-60.
143. Goldstein D, Michler RE. Treatment of cardiac tumors by orthoptic cardiac transplantation. Semin Oncol 1997;24:534-9.
144. Kern JH, Hayes CJ, Michler RE, Gersony WM, Quaegebeur JM. The Norwood procedure for hypoplastic left heart syndrome: Survival and risk factor analysis. Am J Cardiol 1997;80:170-4.
145. Sandhu AA, Spotnitz HM, Dickstein ML, Rose EA, Michler RE. Retrograde cardioplegia preserves myocardial function after induced coronary air embolism. J Thor Cardiovasc Surg 1997;113:917-22.
146. Goldstein DJ, Garfein ES, Aaronson K, Zuech N, Michler RE. Mitral valve replacement and tricuspid valve repair following cardiac transplantation. Ann Thor Surg 1997;63:1463-5.
147. Shane E, Rivas M, McMahon DJ, Staron RB, Silverberg SJ, Seibel MJ, Mancini D, Michler RE, Aaronson K, Addesso V, Hwa Lo, S. Bone loss and turnover after cardiac transplantation. J Clin Endocrinol Metab 1997;82:1497-506.
148. Fricker FJ, Sigfusson G, Bernstein D, Addonizio LJ, Webber SA, Hsu DT, Miller SA, Lawrence K, Miller J, Griffith BP, Reitz BA, Rose EA, Boyle GJ, Michler RE, Douglas JF. Long-term survivors of pediatric heart transplantation: A multicenter report of 68 children who survived greater than five years. J of Pediatr 1997;130:862-71.
149. Michler RE. Review of Jeevanandum Paper. Ann Thor Surg Website.
150. Ashton Jr C, Whitworth GC, Seldomridge JA, Shapiro PA, Weinberg AD, Michler RE, Smith CR, Rose EA, Fisher S, Oz MC. Self-hypnosis reduces anxiety following coronary artery bypass surgery A prospective, randomized trial. J Cardiovasc Surg 1997;38:69-75.
151. Tugulea S, Ciubotariu R, Colovai A, Liu Z, Itesdu S, Schulman L, Fisher P, Hardy M, Rose E, Michler RE, Cortesini R, Suciu-Foca N. New strategies for early diagnosis of heart allograft rejection. Transplantation 1997;64:842-7.
152. Artrip JH, Kwiatkowski PA, Wang S, Minanov OP, Morgenthau A, Michler RE and Itescu S. Interactions between IL-2 activated human natural killer cells and porcine endothelium involves direct binding to galactose a1,3-galactose ligands. Surg Forum 1997;48:491-4.
153. Galili U, Minanov O, Michler RE, Stone KR. High-affinity anti-gal IgG in chronic rejection of xenografts. Xenotransplantation 1997;4:127-31.
154. Ravilli S, Szabolcs M, Albala A, Michler RE, Cannon PJ. Endothelin-1 peptide expression in transplant coronary artery disease. Tranplant Proc 1997;29:2577-8.
155. Suciu-Foca N, Liu Z, Colovai AI, Fisher P, Ho E, Reed EF, Rose EA, Michler RE, Hardy MA, Cocciolo P, Gargano F, Cortesini R. Indirect T-cell recognition in human allograft rejection. Transplant Proc 1997;29:1012-3.
156. Ravalli S, Szabolcs M, Barbone A, Albala A, Michler RE, Cannon PJ. Inducible nitric oxide synthase is upregulated in human transplant coronary artery disease. Transplant Proc 1997;29:2579-80.
157. Kwiatkowski P, Artrip JH, Michler RE, Itescu S. Human NK cells demonstrate increased adherence and lysis of porcine endothelium following activation with IL-2. Ann Transplant 1997;2:21-5.
158. Artrip JH, Itescu S, Minanov OP, Kwiatkowski PA, Michler RE. Cardiac Xenotransplantation. Curr Opin Cardiol 1997;12:172-8.
159. Weinstein S, Horvath KD, Romney BE, Michler RE. Enlarging mediastinal mass after cardiac transplantation. Ann Thor Surg 1997;64:845-7.
160. Argenziano M, Michler RE, Rose EA. Cardiac transplantation for endstage heart disease. Heart Vessels 1997;12:23-7.
161. Artrip JH, Kwiatkowski PA, Michler RE, Itescu S. Immunologic barriers in pig-to-primate cardiac xenotransplantation. Ann Transplant 1997;2:5-11.
162. Itescu S, Artrip JH, Kwiatkowski P, Wang SF, Minanov OP, Morgenthau AS, Michler RE. Lysis of pig endothelium by IL-2 activated human natural killer cells is inhibited by swine and human major histocompatibility complex (MHC) class I gene products. Ann Transplant 1997;2:14-20.
163. Kichuk MR, Zhang X, Oz M, Michler RE, Kaley G, Nasjaletti A, Hintze TH. ACE inhibitors promote nitric oxide production in coronary microvessels from failing explanted human hearts. Am J Cardiol 1997;80:137A?42A.
164. Yang X, Szabolcs M, Minanov O, Ma N, Sciacca RR, Bianchi M, Tracey KJ, Michler RE, Cannon PJ. CNI-1493 prolongs survival and reduces myocyte loss, apoptosis and inflammation during rat cardiac allograft rejection. J Cardiovasc Pharmacol 1998;32:146-55.
165. Shane E, Rodino MA, McMahon DJ, Addesso V, Staron RB, Seibel MJ, Mancini D, Michler RE, Hwa Lo, S. Prevention of bone loss after cardiac transplantation with antiresorptive therapy. J Heart Lung Transplant 1998;17:1089-96.
166. John R, Artrip JH, Michler RE. Genetically engineered organs. Adv Card Surg 1998; 10:229-44.
167. Chadburn A, Chen J, Hsu DT, Frizzera G, Garrett TJ, Mears G, Zangwill S, Addonizio LJ, Michler RE, Knowles DM. The morphologic and molecular genetic classification of posttransplantation lymphoproliferative disorders (PT-LPDs) has clinical relevance. Cancer 1998;82:1978-87.
168. Minanov OP, Artrip J, Szabolcs M, Kwiatkowski P, Galili U, Itescu S, Michler RE. Triple immunosuppression reduces mononuclear cell infiltration and prolongs graft life in pig-to-newborn baboon cardiac xenotransplantation. J Thor Cardiovasc Surg 1998;115:998-1006.
169. Zangwill SD, Hsu DT, Kichuk MR, Garvin JH, Stolar CJH, Haddad Jr. J, Stylianos S, Michler RE, Chadburn A, Knowles DM, and Addonizio LJ. Incidence and outcome of primary Epstein-Barr virus infection and lymphoproliferative disease in pediatric heart transplant recipients. J Heart Lung Transplant 1998;17:1161-6.
170. Schechter WS, Navedo A, Jordan D, Dominguez C, Hall S, Kichuck M, Galantowicz M, Michler RE, Delphin E. Paediatric cardiac anesthesia in a developing country. Paediatr Anesth 1998;8:283-92.
171. Kwiatkowski PA, Artrip JH, Ankersmit J, Schuster M, John R, Wang SF, Ma N, Michler RE, Itescu S. Importance of CD49D-VCAM interactions in human monocyte adhesion to porcine endothelium. Xenotransplantation 1998;5:67-74.
172. Masroor S, Itescu S, Artrip JH, Minanov O, Buelow R and Michler RE. Induction of tolerance in rodent cardiac allotransplantation using an MHC Class-I derived peptide and cyclosporine. Ann Thor Surg 1998;65:144-8.
173. Itescu S, Tung TC, Burke EM, Weinberg A, Moazami N, Artrip JH, Suciu-Foca N, Rose EA, Oz MC, Michler RE. Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation. Circulation 1998;98:786-93.
174. Ravalli S, Albala A, Ming M, Szabolcs M, Barbone A, Michler RE, Cannon PJ. Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease. Circulation 1998;97:2338-45.
175. Mets B, Michler RE, Delphin ED, Oz MC, Landry DW. Refractory vasodilation after cardiopulmonary bypass for heart transplantation in recipients of combined amiodarone and angiotensin-converting enzyme inhibitor therapy: A role for vasopressin administration. J Cardiothor Vasc Anesth 1998;12:326-9.
176. Itescu S, Kwiatkowski P, Artrip JH, Wang SF, Ankersmit J, Minanov OP, Michler RE. Role of natural killer cells, macrophages and accessory molecule interactions, in the rejection of pig-to-primate cardiac xenografts beyond the hyperacute period. Hum Immunol 1998;59:275-86.
177. Szabolcs MJ, Ravalli S, Minanov O, Sciacca RR, Michler RE, Cannon PJ. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation 1998;65:804-12.
178. Cannon P, Yang X, Szabolcs MJ, Ravalli S, Sciacca RR, Michler RE. The role of inducible nitric oxide synthase in cardiac allograft rejection. Cardiovasc Res 1998;38:6-15.
179. Itescu S, Tung TC, Burke EM, Weinberg AD, Mancini D, Michler RE, Suciu-Foca NM, Rose EA. An immunological algorithm to predict risk of high-grade rejection in cardiac transplant recipients. Lancet 1998;352:263-70.
180. Baughman KL, Crawford MH, Michler RE. 30th Bethesda Conference: The future of academic cardiology. J Am Coll of Cardiol 1999;33:1091-135.
181. Kwiatkowski PA, Artrip JH, John R, Edwards NM, Wang SF, Michler RE, Itescu S. Induction of swine major histocompatibility complex (MHC) class I molecules on porcine endothelium by tumor necrosis factor-alpha reduces lysis by human natural killer cells. Transplantation 1999;67:211-8.
182. Kwiatkowski PA, Artrip JH, Lietz K, Edwards NM, Tugulea S, Michler RE, McKenzie IFC, Sandrin MS, Itescu S. High-level porcine endothelial cell expression of alpha (1,2)- fucosyltransferase reduces human monocyte adhesion and activation. Transplantation 1999;67:219-26.
183. Kwiatkowski PA, Artrip JH, Edwards NM, Lietz K, Tugulea S, Michler RE, McKenzie IFC, Sandrin MS, Itescu S. High-level porcine endothelial cell expression of alpha (1,2)- fucosyltransferase reduces human monocyte adhesion and activation. Transplantation 1999;67: editorial discussion 193-4.
184. Artrip JH, Kwiatkowski P, Michler RE, Wang SF, Tugulea S, Ankersmit J, Chisholm L, McKenzie IFC, Sandrin MS, Itescu S. Target cell susceptibility to lysis by human natural killer cells is augmented by alpha(1,3)-galactosyltransferase and reduced by alpha(1,2)- fucosyltransferase. J Biol Chem 1999;274:10717-22.
185. Lamour JM, Addonizio LJ, Galantowicz ME, Quaegebeur JM, Mancini DM, Kichuk MR, Beniaminovitz A, Michler RE, Weinberg A, Hsu DT. Outcome after orthotopic cardiac transplantation in adults with congenital heart disease. Circulation 1999;100:II200-5.
186. Pratt JW, Michler RE, Pala J, Brown DA. Minimally invasive coronary artery bypass grafting for myocardial muscle bridging. Heart Surg Forum 1999;2:250-3.
187. Szabolcs MJ, Cannon PJ, Thienel U, Chen R, Michler RE, Chess L, Yellin MJ. Analysis of CD154 and CD40
expression in native coronary atherosclerosis and transplant associated coronary artery disease. Virchows Arch 2000;437:149-59.
188. Yang X, Ma N, Szabolcs MJ, Zhong J, Athan E, Sciacca RR, Michler RE, Anderson GD, Wiese JF, Leahy KM, Gregory S, Cannon PJ. Upregulation of COX-2 during cardiac allograft rejection. Circulation 2000;101:430-8.
189. Ying AK, Hassanain HH, Ross CM, Smiraglia DJ, Issa JJ, Michler RE, Caligiuri M, Plass C, Goldschmidt PJ. Methylation of the estrogen receptor-alpha gene promoter is selectively increased in proliferating human aortic smooth muscle cells. Cardiovasc Res 2000;46:172-9.
190. Gowdamarajan A, Michler RE. Therapy for primary cardiac tumors: Is there a role for heart transplantation? Curr Opin in Cardiol 2000;15:121-5.
191. Gomez D, Olshove VF, Weinstein S, Davis JT, Michler RE. Use of a low-prime circuit for bloodless heart transplantation in xenotransplant of 5-7 kilogram primates. J Extra?Corp Tech 2000;32:138-41.
192. Itescu S, Kwiatkowski P, Atrip JH, Kocher A, Edwards N, Michler RE. Transendothelial migration and infiltration of porcine xenografts by primate monocytes requires natural killer cell-dependent activation. Transplant Proc 2000;32:1083.
193. John R, Beniaminovitz A, Artrip JH, Rabbani L, Michler RE. The diagnosis and management of aortic dissection occurring years after open heart surgery. J Cardiovasc Surg 2000;41:251-3.
194. Kwiatkowski P, Artrip JH, Michler RE, Wang SF, McKenzie IFC, Sandrin MS, Itescu S. Human monocytes bind to ligands on porcine endothelium containing the gal alpha (1,3)- gal antigen. Transplant Proc 2000;32:931.
195. Kwiatkowski P, Artrip JH, Wang SF, Michler RE, Itescu S. Human monocytes bind to two distinct carbohydrate capping structures on porcine endothelium. Transplant Proc 2000;32:927.
196. Pratt JW, Williams TE, Michler RE, Brown DA. Current indications for left thoracotomy in coronary revascularization and valvular procedures. Ann Thorac Surg 2000;70:1366-70.
197. Stevenson LW, Kormos RL, Bourge RC, Gelijns A, Griffith BP, Hershberger RE, Hunt S, Kirklin J, Miller LW, Pae WE Jr, Pantalos G, Pennington DG, Rose EA, Watson JT, Willerson JT, Young JB, Barr ML, Costanzo MR, Desvigne-Nickens P, Feldman AM, Frazier OH, Friedman L, Hill JD, Konstam MA, McCarthy PM, Michler RE, Oz MC, Rosengard BR, Sapirstein W, Shanker R, Smith CR, Starling RC, Taylor DO, Wichman A. Mechanical cardiac support: Current applications and future trial design. June 15-16, 2000 Bethesda, Maryland. J Am Coll of Cardiol 2001;37:340-70.
198. Stevenson LW, Kormos RL, Barr ML, Costanzo MR, Desvigne-Nickens P, Feldman AM, Frazier OH, Friedman L, Hill JD, Konstam MA, McCarthy PM, Michler RE, Oz MC, Rosengard BR, Sapirstein W, Shanker R, Smith CR, Starling RC, Taylor DO, Wichman A. Mechanical cardiac support 2000: Current applications and future trial design: June 15-16, 2000 Bethesda, Maryland. Circulation 2001;103:337-42.
199. Michler RE. Nanotechnology: Potential applications in cardiothoracic surgery. Biomedical Microdevices 001; 3:2,119-24.
200. Barr ML, Costanzo MR, Desvigne-Nickens P, Feldman AM, Frazier OH, Friedman L, Hill JD, Konstam MA, McCarthy PM, Michler RE, Oz MC, Rosengard BR, Sapirstein W, Shanker R, Smith CR, Starling RC, Taylor DO, Wichman A. Mechanical cardiac support: Current applications and future trial design. J Thor Cardiovasc Surg 2001;121:419-24.
201. Switzer WM, Shanmugam V, Matthews A, Hussain A, Wright A, Sandstrom P, Chapman L, Weber C, Safley S, Denny R, Navarro A, Evans V, Norin A, Kwiatkowski P, Michler RE, Heneine W. Lack of cross-species transmission of porcine endogenous retrovirus infection to nonhuman primate recipients of porcine cells, tissues or organs. Transplantation 2001;71:959-65.
202. Stobierska-Dzierzek B, Awad H, Michler RE. Evolving management of acute right-sided heart failure in cardiac transplant recipients. J Am Coll of Cardiol 2001;38:923-31.
203. Kwiatkowski P, Michler RE. Concordant cardiac xenotransplantation. J Cardiac Surg 2001;16:383-7.
204. Michler RE, Chen JM. Cardiac Xenotransplantation: Ethics and potential application. J Cardiac Surg 2001;16:421-8.
205. Melvin WS, Needleman BJ, Krause KR, Wolf RK, Michler RE, Ellison EC. Computer-assisted "robotic" heller myotomy. J Laparoendosc Adv Surg Tech A 2001;11:251-3.
206. Schneeberger EW, Michler RE. An overview of the intuitive system: The surgeon's perspective. Operative Techniques in Thoracic and Cardiovascular Surgery 2001;6:170-6.
207. Michler RE, Camacho DR. Ex-vivo mitral valve repair prior to orthotopic cardiac transplantation. Ann Thor Surg 2002;73:962-3.
208. Itescu W, Burke E, Lietz K, John R, Mancini D, Michler R, Rose E, Oz M, Edwards N. Intravenous pulse administration of cyclophosphamide is an effective and safe treatment for sensitized cardiac allograft recipients. Circulation 2002;105:1214-9.
209. Michler RE, Gowdamarajan A, Abrishamchian AR, Noberto J. Minimally invasive mitral valve replacement and multivessel coronary artery bypass through a limited right lateral thoracotomy using a balloon aortic cannula. Heart Surg Forum. 2002;5:49-51.
210. Angouras DC, Michler RE. An alternative surgical approach to facilitate minimally invasive mitral valve surgery. Ann Thor Surg 2002;73:673-4.
211. Kwiatkowski P, Juszczak M, Mrozek A, Wilgus J, Fiedor P, Michler RE. Generation of H(2)O(2) prevents Fc receptor-mediated changes in redox potential, reducing beta integrin avidity and natural killer cell adhesion to porcine endothelium. Transplant Proc 2002;34:691-3.
212. Ono M, Wolf RK, Angouras DC, Brown DA, Goldstein AH, Michler RE. Short-and long-term results of open heart surgery in patients with abdominal solid organ transplant. Eur J Cardiothorac Surg 2002;21:1061-72.
213. Kambara A, Michler RE. Dextrocardia: Technical aspects of reoperative aortic and tricuspid valve replacement. J Cardiac Surg 2002;17:163-5.
214. Sun D, Huang A, Mital S, Kichuk M, Marboe C, Addonizio LJ, Michler RE, Koller A, Hintze TH, Kaley G. Norepinephrine elicits b2-receptor-mediated dilation of isolated human coronary arterioles. Circulation 2002;106:550-5.
215. Wang T, Dong C, Stevenson SC, Herderick E, Marshall-Neff J, Vasudevan SS, Moldovan NI, Michler RE, Movva NR, Goldschmidt-Clermont PJ. Overexpression of solubale fas attenuates transplant arteriosclerosis in rat aortic allograts. Circulation 2002;106:1536-42.
216. Melvin WS, Needleman BJ, Krause KR, Schneider C, Wolf RK, Michler RE, Ellison EC. Computer enhanced "robotic" telesurgery: Initial experience in foregut surgery. Surgical Endoscopy 2002;16:1790-2.
217. Abrishanchian AR, Gowdamarajan A, Michler RE. Saphenous vein graft aneurysm: Potential for mistaken identity. J Cardiac Surg 2002;17:295-7.
218. Kwiatkowski PA, Artrip JH, John R, Wang SF, McKenzie IFC, Sandrin MS, Michler RE, Itescu S. Adherence of human monocytes to porcine endothelium involves C-type lectins and sialylated porcine ligands analogus to GlyCAM. Am J Transpl 2004 (Submitted).
219. Itescu S, Kwiatkowski P, Artrip JH, Minanov OP, Michler RE. Monocyte infiltration and rejection of porcine xenografts is dependent on natural killer cell-derived cytokines. Xenotransplantation 2004 (Submitted).
220. Ono M, Michler RE. Beating heart coronary artery bypass surgery after orthotopic heart Transplantation. J Card Surg. 2003 Nov-Dec;18(6):545-9.
221. Ono M, Wolf RK, Schneeberger EW, Brown D, Michler RE. Robotically assisted internal thoracic artery mobilization: Initial experience in the United States and 1-year follow-up. J Thor Cardiovasc Surg 2002 (Submitted).
222. Kwiatkowski PA, Artrip JH, Michler RE, Choi S, Wang SF, McKenzie IFC, Sandrin M, Itescu S. Indirect human T cell recognition of porcine xenoantigens is dependent on monocyte binding to alpha(1,3)- galactosylated ligands and reduced by carbohydrate remodeling. Am J Transpl 2004 (Submitted).
223. Michler RE, Angouras D. Valvular disease: Surgical perspectives. J Am Coll of Cardiol 2002;6:32-38.
224. Michler RE, Angouras DC. Surgical Perspectives. American College of Cardiology, ACCSAP 2005.
225. Michler RE, Kwiatkowski P. Current advances in robotic heart surgery and nanotechnology. Cardiovascular Engineering 2003;8:14-19.
226. Salamon T, Michler RE, Knott KM, Brown DA. Off-pump coronary artery bypass grafting does not decrease the incidence of atrial fibrillation. Ann Thorac Surg 2003;75:505-7.
227. Hassanain H, Irshaid F, Sarker K, Al-kheraije K, Wisel S, Sheridan J, Michler RE, Goldschmidt-Clermont P. Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair. Surgery. 2005 Jan;137(1):92-101.
228. McConnell PI, Michler RE. Surgical restoration of the remodeled left ventricle. Coronary Artery Disease. 2004 Mar;15(2):91-98.
229. McConnell PI, Schneeberger EW, Michler RE. History and development of robotic cardiac surgery. Problems in General Surgery 2003;20:62-72.
230. McConnell PI, Michler RE. Clinical trials in the surgical management of congestive heart failure: surgical ventricular restoration and autologous skeletal myoblast transplantation. Cardiology. 2004;101(1-3):48-60.
231. McConnell PI, Michler RE. Surgical ventricular restoration and other surgical approaches to heart failure. Curr Heart Fail Rep. 2004Apr-May;1(1):21-9.
232. Doenst T, Velazquez EJ, Beyersdorf, F, Michler RE, Menicanti L, DiDonato M, Gradinac S, Sun B, Rao V. To STICH or not to STICH - We Know the Answer but Do We Understand the Question? J Thor Cardiovasc Surg. 2005 Feb;129(2):246-9.
233. Kwiatkowski P, Thelitz S, Gowdamarajan A, Schertel ER, Pemberton P, Phillips AJ, Wisel S, Fiedor P, Michler RE. HK-Cardiosol versus University of Wisconsin solution for 4-6 hour cold heart preservation in an orthotopic pig heart transplantation model. Ann Transpl 2004 (Submitted).
234. Firstenberg, MS, Sai-Sudhakar CB, Raman, SV, Michler, RE. Technical considerations for myocardial revascularization in congenital bilateral hypoplasia of the pericardium. Ann Thorac Surg. 2006 Jan;81(1):352-4.
235. McConnell PI, Michler RE. Surgical ventricular restoration: reshaping the adversely remodeled left ventricle. Coron Artery Dis. 2004 Mar;15(2):91-8.
236. Mehra MR, Zucker M, Wagoner L, Michler R, Boehmer J, Kovarik J, Vasquez A. A multi-center, prospective, randomized, double-blind trial of basiliximab in heart transplantation. J Heart Lung Transplant. 2005 Sept;24(9):1297-304.
237. Dzwonczyk R, Del Rio C, Brown DA, Michler RE, Wolf RK, Howie MB. Myocardial electrical impedance responds to ischemia and reperfusion in humans. IEEE Trans Biomed Eng. 2004 Dec:51(12);2206-9.
238. Baumgartner WA, Burrows S, Del Nido PJ, Gardner TJ, Goldberg S, Gorman RC, Letsou GA, Mascette A, Michler RE, Puskas JD, Rose EA, Rosengart TK, Sellke FW, Shumway SJ, Wilke N. Recommendations of the National Heart, Lung, and Blood Institute working group on future direction in cardiac surgery. Circulation. 2005 Jun 7;111(22):3007-13.
239. Simsic JM, Scheurer M, Tobias JD, Berkenbosch J, Schechter WS, Madera F, Weinstein S, Michler R,. Perioperative hemodynamic effects and safety of Neseritide following cardiac surgery in children. J Intensive Care Med. 2006 Jan-Feb;21(1):22-6.
240. McConnell PI, del Rio CL, Jacoby DB, Zawadzka A, Dinsmore JH, Kwiatkowski P, Michler RE. Correlation of autologous skeletal myoblast survival with changes in left ventricular remodeling in dilated ischemic heart failure. J Thorac Cardiovasc Surg 2005 Oct;130(4):1001-9.
241. Dib N, Michler RE, Pagani FD, Wright S, Kereiakes DJ, Lengerich R, Binkley P, Buchele D, Anand I, Swingen C, Di Carli MF, Thomas JD, Jaber WA, Opie SR, Campbell A, McCarthy P, Yeager M, Dilsizian V, Griffith BP, Korn R, Kreuger SK, Ghazoul M, MacLellan WR, Fonarow G, Eisen HJ, Dinsmore J, Diethrich E. Safety and Feasibility of Autologous Myoblast Transplantation in Patients with Ischemic Cardiomyopathy: Four-Year Follow-Up. Circulation. 2005;112:1748-55.
242. del Rio CL, McConnell PI, Clymer BD, Dzwonczyk R, Michler RE, Billman GE, Howie MB. Early time course of myocardial electrical impedance during acute coronary artery occlusion in pigs, dogs and humans. J Appl Physiol. 2005 Oct;99(4):1576-81. Epub 2005 Jun 16.
243. Dib N, McCarthy P, Campbell A, Yeager M, Pagani FD, Wright S, MacLellan WR, Fonarow G, Eisen HJ, Michler RE, Binkley P, Buchele D, Korn R, Ghazoul M, Dinsmore J, Opie SR, Diethrich E. Feasibility and safety of autologous myoblast transplantation in patients with ischemic cardiomyopathy. Cell Transplant.
2005;14(1):11-9.
244. Goldstein DJ, Smego D, Michler RE. Surgical aspects in congestive heart failure. Heart Fail Rev. 2006 Jun; 11(2):171-92.
245. Lozonschi L, Sirak J, Michler RE. Transaortic Delivery of the Transmitral Lesion in a Complete Maze Procedure. Ann of Thor Surg, 2007 in press.
246. McConnell PI, del Rio CL, Kwiatkowski P, Farrar DJ, Michler RE, Sun BC. Novel Evaluation of Cardiac Function during Axial Flow LVAD Support Using a Left Ventricular Pressure-Derived Index: Comparison with Preload Recruitable Stroke Work. Submitted to J Heart Lung Transplant.
247. McConnell PI, del Rio CL, Dzwonczyk R, Clymer BD, Michler RE, Howie MB. Time course of electromechanical changes during acute coronary artery microemolization and complete occlusion. Submitted to Cardiovascular Research.
248. Dzwonczyk R, del Rio CL, Sai-Sudhakar C, Sirak JH, Michler RE, Sun B, Kelbick N, Howie MB. Vacuum-assisted apical suction devices induce passive electrical changes consistent with myocardial ischemia during off-pump coronary artery bypass graft surgery. Eur J Cardiothorac Surg. 2006 Dec;30(6):873-6.
Book Chapters
1. Michler RE, Rose EA, Malm JR. Tricuspid Artesia. In: Pediatric Cardiac Surgery. Arciniegas E (Ed). Yearbook Medical Publishers, Inc., Chicago. 1985.
2. Sanchez JA, Michler RE, Rose EA, Cooper DKC. Experimental xenotransplantation between closely related primate species. In: Xenotransplantation: The Transplantation of Organs Between Species. Cooper DKC, Kemp E, Reemtsma K, White DJG (Eds). Spring?Verlag, Berlin Heidelberg. 1991.
3. Michler RE. Xenotransplantation. In: Atlas of Heart and Lung Transplantation. Kapoor A (Ed). McGraw Hill Publishing Co., New York. 1993.
4. Michler RE. Pediatric lung transplantation. In: Atlas of Heart and Lung Transplantation. Kapoor A (Ed). McGraw Hill Publishing Co., New York. 1993.
5. Michler RE, Chen JM, Mancini DM, Reemtsma K, Rose EA. Sixteen years of cardiac transplantation: The Columbia?Presbyterian Medical Center Experience 1977?1993. In: Clinical Transplants 1993. Terasaki PI (Ed). UCLA Tissue Typing Laboratory, Los Angeles. 1994.
6. Michler RE, Chen JM. Alternatives to lung allotransplantation: Clinical potential and future prospects. In: Current Topics in General Thoracic Surgery: An International Series, Vol. 3 Lung Transplantation. Patterson GA (Ed). Elsevier Science B.V., New York. 1994.
7. Michler RE, Chen JM, Rose EA. Cardiac xenotransplantation: Insurmountable barrier or clinical reality? In: Advances in Cardiac Surgery, Vol. 5. Karp RB, Wechsler AS (Eds). Mosby?Year Book, Inc., Chicago. 1994.
8. Michler RE, Reemtsma K. Cardiac transplantation: The case for xenografts. In: Thoracic Transplantation. Shumway SJ, Shumway NE (Eds). Blackwell Scientific Publications Inc., Massachusetts. 1995.
9. Ratner AJ, Rose EA, Michler RE. Xenografts. In: Encyclopedia of Bioethics. Solberg M (Ed). MacMillan Publishing Co., New York. 1995.
10. Michler RE, Chen JM. Cardiac xenotransplantation: Experimental advances, ethical issues, and clinical potential. In: Cardiac Transplantation. Emery R, Miller L (Eds). Hanley and Belfus, Philadelphia. 1995.
11. Ravalli S, Marboe CC, D'Agati VD, Michler RE, Sigal E, Cannon PJ. Immunohistochemical demonstration of 15?lipoxygenase in transplant?associated coronary artery disease. In: Advances in Prostaglandin, Thromboxane, and Leukotriene Research, Vol. 23. Samuelsson, Paoletti and Ramwell (Eds). Raven Press, New York. 1996.
12. Kichuk MR, Itescu S, Michler RE, Addonizio LJ. Transplant immunology and pediatric immunosuppression. In: Pediatric Cardiopulmonary Transplantation. Franco K (Ed). Futura Publishing, Inc., New York. 1997.
13. Addonizio LJ, Kichuk M, Chen JM, Michler RE. Benefits and pitfalls of transplantation for patients with congenital heart disease. In: Pediatric Cardiopulmonary Transplantation. Franco K (Ed). Futura Publishing, Inc., New York. 1997.
14. Chen JM, Michler RE. The problem of pulmonary hypertension in the potential cardiac transplant recipient. In: The Transplantation and Replacement of Thoracic Organs. Cooper DKC, Miller LW, Patterson GA (Eds). Kluwer Academic Publishers, Lancaster, UK. 1997.
15. Michler RE. Xenotransplantation considered. In: 1997 Medical and Health Annual. Encyclopedia Britannica, Inc., Chicago. 1997.
16. Itescu S, Shah AS, Artrip JH and Michler RE. Immunobiology of pig?to?baboon lung xenotransplantation. In: Xenotransplantation: The Transplantation of Organs and Tissues Between Species, 2nd Edition. Cooper DKC, Kemp E, Reemtsma K and White DJG (Eds). Spring-Verlag, New York. 1997.
17. Itescu S, Minanov OP, Michler RE. Newborn pig?to?baboon cardiac xenotransplantation: A model of delayed xenograft rejection. In: Xenotransplantation: The Transplantation of Organs and Tissues Between Species. 2nd Edition. Cooper DKC, Kemp E, Platt JL, White DJG (Eds). Springer?Verlag, New York. 1997.
18. Michler RE, Chen JC, Itescu S, Mancini D, Oz M, Smith CR, Rose EA. Two decades of transplantation at the Columbia-Presbyterian Medical Center 1977-1997. In: Clinical Transplants 1996. Terasaki PI (Ed). UCLA Tissue Typing Laboratory, Los Angeles. 1997.
19. Itescu S, Artrip JH, Shah AS, Michler RE. Pig-to-primate lung xenotransplantation. In: Lung Transplantation. Cooper DKE, Patterson GA, Turlock R (Eds). Elsevier Science B.V., New York. 1997.
20. Michler RE, Chen JM. Recent advances in heart surgery: Minimally invasive surgery, laser revascularization and the Batista operation. In: 1998 Medical and Health Annual. Encyclopedia Britannica, Inc., Chicago. 1997.
21. Atrip J, Minanov OP, Itescu S, Michler RE. Xenotransplantation. In: Management of End-Stage Heart Disease. Rose EA, Stevenson LW (Eds). Little Brown Publishing, New York. 1997.
22. John R, Atrip JH, Michler RE. Genetically engineered organs. In: Advances in Cardiac Surgery. Karp R, O'Brien G (Eds). Mosby, Inc., St. Louis. 1998.
23. Michler RE, Schneeberger EW. Heart transplantation: Technical tips to the surgical procedure. In: Immunogentics. Norman D, Turka L (Eds). Blackwell Science Ltd., Mount Laurel. 2001.
24. Harter RL, Michler RE. Circulatory assist devices. In: A Practical Approach to Cardiac Anesthesia. Hensley F, Martin D, Gravlee G (Eds). Lippincott Williams & Wilkins, Philadelphia. 2002.
25. Woda R, Michler RE. Postoperative care of the cardiac surgical patient. In: A Practical Approach to Cardiac Anesthesia. Hensley F, Martin D, Gravlee G (Eds). Lippincott Williams & Wilkins, Philadelphia. 2002.
26. D'Alessandro DA, Michler RE. Heart-Lung Machines. In: The Wiley Encyclopedia of Medical Devices and Instrumentation, Second Edition. Ed. John G. Webster. Hoboken, NJ: John Wiley & Sons, Inc., 2007 in press.
27. Ashton AW, D'Alessandro D, Michler RE. Use of Skeletal Myoblasts for the Treatment of Congestive Heart Failure. In: Contemporary Cardiology: Stem Cells and Myocardial Regeneration Ed. MS Penn. Humana Press Inc., Totowa, NJ, 2006.
28. Michler RE, Zembala M, Goldstein DJ. Surgical Approach to Heart Failure. In: Heart Failure: A Practical Approach to Therapy, 1edition, Ed. Abraham and Krum. McGraw Hill, 2007 in press.
29. Michler RE. Mitral Valve Repair. In: HeartValveSAP. Ed. H.Boudoulas. American College of Cardiology. 2006. CD ROM/Online educational program; https://www.cardiosource.com/sapsInfo/index.asp.
30. Michler RE. Surgical Ventricular Reconstruction for Congestive Heart Failure. In Braunwald's Heart Disease, 7th E-dition. Elsevier, 2007 in press.
Specialty Publications
1. Michler RE. Minimally invasive cardiac surgery. Zollinger Postgraduate Course in Surgery. Proceedings of the Fourth Annual Course. 1998,1:47-8.
2. Michler RE. Heart replacement for end-stage heart disease: Xenotransplantation considered. Zollinger Postgraduate Course in Surgery. Proceedings of the Fourth Annual Course. 1998;1:55-9.
3. Michler RE, Fox IJ, Hardy MA. Pediatric organ transplantation: History, current status, and important trends. Monograph. Sandoz Pharmaceuticals 1992.
4. Michler RE. Physiology of Left/Right Shunts. Perma-Flow 1995.
Selected Abstracts
1. Ventura H, Kirklin J, Eisen H, Michler RE, Clemson B, O'Donnell J, Dumas-Hicks D, Porter C, Naftel D, McGiffin D. The combined impact of pretransplant risk factors and rejection frequency and severity on the prevalence of posttransplant coronary vasculopathy. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
2. Krishnan US, Hsu DT, Donnelly CM, Kichuk MR, Martin EC, Michler RE, Quaegebeur JM, Addonizio LJ. Management of aorto-pulmonary collaterals in children following heart transplant for complex congenital heart disease. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
3. Addonizio LJ, Kichuk MR, Hsu DT, Douglas JF, Fountain KS, Galantowicz ME, Michler RE, Quaegebeur JM. Improved survival following pediatric cardiac retransplantation using total lymphoid irradiation. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
4. Itescu S, Weinberg AD, Burke EM, Tung TC, Rose EA, Oz MC, Suciu-Foca N, Michler RE. Influence of pre-formed IGG anti-HLA antibodies on development of cellular rejection in highly sensitized cardiac allograft recipients. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
5. Suciu-Foca N, Ciubotariu R, Tugalea S, Colovai AI, Liu Z, Itescu S, Cortesini R, Hardy MA, Rose EA, Michler RE. New strategies for early diagnosis and treatment of heart allograft rejection. ISHLT. (Annual meeting & scientific session, London, England: 4/2 -5 /97).
6. Argenziano M, Choudhri AF, Salehizadeh BM, Moazami N, Levin HR, Rose EA, Michler RE, Landry DW, Oz MC. Arginine vasopressin in the treatment of vasodilatory shock after heart transplantation. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
7. Itescu S, Burke EM, Weinberg AD, Levin H, Bosworth B, Spanier T, Rose EA, Suciu-Foca NM, Michler RE, Oz MC. B Cell hyperreactivity in recipients of left ventricular assist devices (LVAD): Association of HLA-DR3 with anti-HLA antibodies. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
8. Shane E, Thys-Jacobs S, Papadopoulas A, Addesso V, Mancini D, Seibel NJ, Michler RE, Staron RB. Bone loss after cardiac transplantation (CTX) is prevented by antiresorptive drugs. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
9. Minanov OP, Itescu S, Kwiatkowski P, Artrip J, Galili U, Michler RE. Effects of triple immunosuppression in pig-to-newborn baboon cardiac xenotransplantation. ISHLT. (Annual meeting & scientific session, London, England: 4/2 - 5/97).
10. Itescu S, Burke E, Mancini D, Rose E, Suciu-Foca N, Michler R. Certain HLA-DR types in the donor heart are associated with accelerated coronary artery disease (CAD) in transplant recipients. (Annual meeting and scientific session, New York City, NY: 3/15 - 18/96).
11. Itescu S, Burke E, John R, Weinberg A, Mancini D, Suciu-Foca N, Rose E, Edwards N, Oz M, Michler R. Improved outcome in highly sensitized cardiac transplant recipients using intravenous cyclophosphamide. ISHLT. (Annual meeting & scientific session, Chicago, IL: 4/15 - 18/98).
12. John R, Burke E, Mancini D, Suciu-Foca N, Edwards N, Michler R, Rose E, Oz M, Itescu S. Intravenous immunoglobulin versus cyclophosphamide and plasmapheresis for reduction of anti-HLA antibodies in highly sensitized patients awaiting cardiac transplantation. ISHLT. (Annual meeting & scientific session, Chicago, IL: 4/15 - 18/98).
13. Itescu S, Tung T, Burke E, Suciu-Foca N, Edwards N, Michler R, Rose, E. Concomitant use of lymphocyte growth assay and anti-HLA antibodies for prediction of high-grade cellular rejection in cardiac allograft recipients. ISHLT. (Annual meeting & scientific session, Chicago, IL: 4/15 - 18/98).
14. Navedo AT, Schechter WS, Jordan D, Moquette E, Gaffney, J, Michler RE, Heart Care International Team. In-hospital mortality for volunteer pediatric cardiac surgery missions in Guatemala. 1999 (Submitted).
15. Itescu S, Kwiatkowski P, Artrip J, Kocher A, Minanov O, Michler RE. Transendothelial migration and infiltration of porcine xenografts by primate monocytes requires natural killer (NK) cell-dependent activation and is sensitive to corticosteroids. Transplant 2000;69:S253 (First Joint Annual Meeting of the ASTS and AST Chicago, IL: 5/13-17/2000).
16. Kwiatkowski P, Artrip J, Wang S, Michler RE, Itescu S. Two distinct capping structures on porcine endothelium bind to human monocytes, and their assembly can be reduced by high-level expression of alpha (1,2)-fucosyltransferase. Transplant 2000;69S383 (First Joint Annual Meeting of the ASTS and AST, Chicago IL: 5/13-17/2000).
17. Kwiatkowski P, Wang S, Edwards N, Michler RE, Itescu S. Generation of H202 prevents Fc receptor-mediated changes in redox potential, reducing beta integrin avidity and NK cell adhesion to porcine endothelium. Transplant 2000;69:S383 (First joint annual meeting of the ASTS and AST, Chicago, IL: 5/13-17/2000).
18. Hassanain HH, Irshaid F, Al-kheraije K, Michler RE, Goldschmidt-Clermont PJ. Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates wound repair. (2001 Keystone Symposia for Angiogenesis and Chronic Diseases & Cellular and Molecular Events in the Pathogenesis of Atherosclerosis, Keystone, Colorado: 4/24-29/2001).
19. Richardson KA, Michler RE, Wolf RK, Brown DA. Minimally invasive direct coronary artery bypass versus off-pump coronary artery bypass: A study in clinical appropriateness in 226 patients. J Am Coll of Cardiol 2001;38:345A-346A.
20. Ono M, Wolf RK, Angouras DC, Brown DA, Golstein AH, Michler RE. Short- and long-term results of open-heart surgery in patients with abdominal solid organ transplant. Eur J Cardiothorac Surg 2002;21:1061-72.
21. Al-kheraije K, Wisel S., Michler RE, Hassanain H. Changes in actin dynamics lead to the activation of the hypertrophic signaling cascade in the vascular smooth muscle cells of a transgenic mouse model. AHA 75th Scientific Sessions, Chicago. Nov. 17-21, 2002.
22. Al-kheraije K, Wisel S, Rigatto KV, Mitchell SA, Morris M, Michler RE, Hassanain H. Expression of profilin in vascular smooth muscle cells leads to vascular hypertrophy and hypertension in a transgenic mouse model. AHA 75th Scientific Sessions, Chicago. Nov. 17-21, 2002.
23. Dib N, McCarthy P, Campbell A, Dinsmore J, Yeager M, MacLellan WR, Fonarow G, Michler RE, Buchele D, Ghazoul M, Diethrich E. Safety and feasibility of autologous myoblast transplantation in patients undergoing coronary artery bypass grafting: results from the United States experience. AHA 75th Scientific Sessions, Chicago. Nov. 17-20, 2002.
24. Astra LI, Williams TE, Michler RE. Multivariate analysis of 2,300 patients demonstrates minimal influence of obesity on outcomes for coronary bypass surgery. JACC 2003;3:530A.
25. McConnell PI, Astra L, Schneeberger EW, Jacoby DB, Dinsmore J, Michler RE. Autologous skeletal myoblasts prevent left ventricular dilatation without improving cardiac function. J Card Fail. 2003; 9 [suppl]: S28. Finalist for the Jay N. Cohn Award, Heart Failure Society of America.
26. McConnell PI, Michler RE, Dzwoncyzyk R, del Rio C and Howie MB. Myocardial electrical impedance responds to induced ischemia and surgical reperfusion in humans. American College of Surgeons, Chicago, IL, 10/19-10/23/03.
27. Howie MB, McConnell PI, del Rio CL, Dzwonczyk R, Jacoby DB and Michler RE. Autologous skeletal myoblasts restore the electrical impedance of infracted sheep myocardium. Anesth Analg. 2004; 98: S-25. Presentation awarded 2nd place overall.
28. del Rio CL, McConnell PI, Dzwonczyk R, Clymer BD, Michler RE, Howie MB. Myocardial impedance as a monitor of coronary microembolization. Anesth Analg. 2004; 98:SCA80.
29. McConnell PI, del Rio CL, Astra L, Kushnir V, Brunner M, Dinsmore JH, Zawadzka A, Jacoby DB, Kwiatkowski P and Michler RE. Autologous Skeletal Myoblast Survival Correlates with Changes in Left Ventricular Remodeling in Dilated Ischemic Heart Failure. WTSA 2004. Finalist for the Paul C. Sampson Award.
30. McConnell PI, del Rio CL, Zawadzka, A, Jacoby DB, Kwiatkowski P, Wisel S, Howie M, Michler RE. Autologous skeletal myoblasts restore the myocardial electrical impedance of infarcted myocardium, but not the refractory period: engraftment versus integration. J Card Fail. 2004; 10 [suppl]: S20. Winner of the Jay N. Cohn Award, Heart Failure Society of America.
31. McConnell PI, del Rio CL, Dzwonczyk R, Kwiatkowski P, Clymer BD, Howie MB, Michler RE. Correlation between myocardial uncoupling and left ventricular remodeling in experimental dilated ischemic heart failure. JACC. 2005; 45(3) [Suppl A]: A184.
32. McConnell PI, del Rio CL, Kwiatkowski P, Farrar D, Shipkowitz T, Michler RE and Sun B. A novel technique for assessing load-dependent cardiac function during LVAD support using telemetered left ventricular pressure. ASAIO J. 2005; 51(2): A31. Won Poster Presentation Award.
33. McConnell PI, del Rio CL, Kwiatkowski P, Jacoby DB, Zawadzka A, Michler RE. Improved Left Ventricular Performance after Autologous Skeletal Myoblast Transplantation in Ischemic Heart Failure: Contribution of the Remote versus the Transplanted Myocardium. J Card Fail. 2005; 11(6) Suppl: S105.
34. McConnell PI, del Rio CL, Kwiatkowski P, Jacoby DB, Zawadzka A, Michler RE. Improved remote myocardial reserve after autologous skeletal myoblast transplantation in ischemic heart failure. J Card Fail. 2005; 11(6) Suppl: S105
35. McConnell PI, del Rio CL, Kwiatkowski P, Michler RE. Remote myocardial remodeling outpaces infarct expansion in experimental ischemic heart failure. J Card Fail. 2005; 11(6) Suppl: S114.
36. del Rio CL, McConnell PI, Dzwonczyk R, Kwiatkowski P, Clymer BD, Howie MB, Michler RE. Correlation between cell-to-cell coupling and LV global/cellular remodeling in the failing heart. J Card Fail. 2005; 11(6) Suppl: S114.
37. del Rio CL, McConnell PI, Dzwonczyk R, Clymer BD, Howie MB, Billman GE. B2-Adrenergic activation enhances ischemia-induced cell-cell uncoupling in animals susceptible to sudden death. American Heart Association Scientific Sessions 2005.
38. del Rio CL, McConnell PI, Dzwonczyk R, Michler RE, Howie MB. Time course of isoflorane-induced changes on myocardial electrical impedance: an online marker of delayed preconditioning? Amer. Society Anesthesiology 2005.
39. McConnell PI, del Rio CL, Kwiatkowski P, Jacoby DB, Zawadzka A, Michler RE. Remote myocardial function contributes to improved left ventricular performance and remodeling after autologous skeletal myoblast transplantation in ischemic heart failure. International Society of Heart and Lung Transplantation 26th Annual Meeting, Madrid, Spain, April 5-8, 2006.
40. McConnell PI, del Rio CL, Kwiatkowski P, Farrar D, Shipkowitz T, Michler RE and Sun B. The Assessment of preload-dependent cardiac function during LVAD support using telemetered left ventricular pressure: A comparison to preload recruitable stroke work. . International Society of Heart and Lung Transplantation 26th Annual Meeting, Madrid, Spain, April 5-8, 2006.