Hoby Hetherington, Ph.D.

Chu WJ, Kuzniecky RI, Hugg JW, Abou-Khalil B, Gilliam F, Faught E, Hetherington HP (2000) Statistically driven identification of focal metabolic abnormalities in temporal lobe epilepsy with corrections for tissue heterogeneity using 1H spectroscopic imaging. Magn Reson Med 43:359-367 

Larson-Meyer DE, Newcomer BR, Hunter GR, Hetherington HP, Weinsier RL (2000) 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake. NMR Biomed 13:14-27 

Larson-Meyer DE, Newcomer BR, Hunter GR, McLean JE, Hetherington HP, Weinsier RL (2000) Effect of weight reduction, obesity predisposition, and aerobic fitness on skeletal muscle mitochondrial function. Am J Physiol Endocrinol Metab 278:E153-E161 

Hetherington HP, Spencer DD, Vaughan JT, Pan JW (2000) Quantitative 31P spectroscopic imaging of human brain at 4T: assessment of gray and white matter differences of phosphocreatine and ATP. Magn Reson Med In press: 

Hwang JH, Pan JW, Hetherington HP, Heydari S, Stein DT (2000) Regional differences in intramyocellular lipids in humans observed by in vivo 1H spectroscopic MR imaging. Am J Physiol In press: 

Pan JW, Stein DT, Telang F, Lee JH, Heydari S, Shen J, Brown P, Cline G, Mason GF, Shulman GI, Rothman DL, Hetherington HP (2000) Spectroscopic imaging of glutamate C-4 turnover in human brain. Magn Reson Med In press: 

Pan JW, Rothman DL, Behar KL, Stein DT, Hetherington HP (2000) Human brain b-hydroxybutyrate and lactate increase in fasting induced ketosis. J Cereb Blood Flow Metab In press: 

Sammi M, Pan JW, Telang F, Schuhlein D, Molina PE, Volkow ND, Springer CS, Hetherington HP (2000) Measurements of human brain ethanol T2 by spectroscopic imaging at 4T. Magn Reson Med In press: 

Shen J, Rothman DL, Hetherington HP, Pan JW (1999) Linear projection method for automatic slice shimming. Magn Reson Med 42:1082-1088 

Martin R, Kuzniecky R, Ho S, Hetherington H, Pan J, Sinclair K, Gilliam F, Faught E (1999) Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults [see comments]. Neurology 52:321-327 

Hetherington HP, Telang F, Pan JW, Sammi M, Schuhlein D, Molina P, Volkow ND (1999) Spectroscopic imaging of the uptake kinetics of human brain ethanol. Magn Reson Med 42:1019-1026 

Kuzniecky R, Hugg J, Hetherington H, Martin R, Faught E, Morawetz R, Gilliam F (1999) Predictive value of 1H MRSI for outcome in temporal lobectomy. Neurology 53:694-698 

Mason GF, Pan JW, Chu WJ, Newcomer BR, Zhang Y, Orr R, Hetherington HP (1999) Measurement of the tricarboxylic acid cycle rate in human grey and white matter in vivo by 1H-[13C] magnetic resonance spectroscopy at 4.1T. J Cereb Blood Flow Metab 19:1179-1188 

Newcomer BR, Boska MD, Hetherington HP (1999) Non-P(i) buffer capacity and initial phosphocreatine breakdown and resynthesis kinetics of human gastrocnemius/soleus muscle groups using 0.5 s time-resolved (31)P MRS at 4.1 T. NMR Biomed 12:545-551 

Pan JW, Lane JB, Hetherington H, Percy AK (1999) Rett syndrome: 1H spectroscopic imaging at 4.1 Tesla. J Child Neurol 14:524-528 

Pan JW, Bebin EM, Chu WJ, Hetherington HP (1999) Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T. Epilepsia 40:703-707

Kuzniecky R, Hetherington H, Ho S, Pan J, Martin R, Gilliam F, Hugg J, Faught E (1998) Topiramate increases cerebral GABA in healthy humans. Neurology 51:627-629 

Kuzniecky R, Hugg JW, Hetherington H, Butterworth E, Bilir E, Faught E, Gilliam F (1998) Relative utility of 1H spectroscopic imaging and hippocampal volumetry in the lateralization of mesial temporal lobe epilepsy. Neurology 51:66-71 

Hetherington HP, Newcomer BR, Pan JW (1998) Measurements of human cerebral GABA at 4.1 T using numerically optimized editing pulses. Magn Reson Med 39:6-10 

Mason GF, Chu WJ, Vaughan JT, Ponder SL, Twieg DB, Adams D, Hetherington HP (1998) Evaluation of 31P metabolite differences in human cerebral gray and white matter. Magn Reson Med 39:346-353 

Pan JW, Twieg DB, Hetherington HP (1998) Quantitative spectroscopic imaging of the human brain. Magn Reson Med 40:363-369 

Zhang Y, Hetherington HP, Stokely EM, Mason GF, Twieg DB (1998) A novel k-space trajectory measurement technique. Magn Reson Med 39:999-1004 

Chu WJ, Hetherington HP, Kuzniecky RI, Simor T, Mason GF, Elgavish GA (1998) Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T. Neurology 51:472-479 

Hetherington HP, Pan JW, Chu WJ, Mason GF, Newcomer BR (1997) Biological and clinical MRS at ultra-high field. NMR Biomed 10:360-371 

Kuzniecky R, Hetherington H, Pan J, Hugg J, Palmer C, Gilliam F, Faught E, Morawetz R (1997) Proton spectroscopic imaging at 4.1 tesla in patients with malformations of cortical development and epilepsy. Neurology 48:1018-1024 

Pan JW, Mason GF, Vaughan JT, Chu WJ, Zhang Y, Hetherington HP (1997) 13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T. Magn Reson Med 37:355-358 

Mason GF, Harshbarger T, Hetherington HP, Zhang Y, Pohost GM, Twieg DB (1997) A method to measure arbitrary k-space trajectories for rapid MR imaging. Magn Reson Med 38:492-496 

Mason GF, Chu WJ, Hetherington HP (1997) A general approach to error estimation and optimized experiment design, applied to multislice imaging of T1 in human brain at 4.1 T [published erratum appears in J Magn Reson 1997 Jul;127(1):134-6]. J Magn Reson 126:18-29 

Chu WJ, Hetherington HP, Kuzniecky RJ, Vaughan JT, Twieg DB, Faught RE, Gilliam FG, Hugg JW, Elgavish GA (1996) Is the intracellular pH different from normal in the epileptic focus of patients with temporal lobe epilepsy? A 31P NMR study. Neurology 47:756-760 

Hetherington HP, Pan JW, Mason GF, Adams D, Vaughn MJ, Twieg DB, Pohost GM (1996) Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magn Reson Med 36:21-29 

Hugg JW, Kuzniecky RI, Gilliam FG, Morawetz RB, Fraught RE, Hetherington HP (1996) Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging. Ann Neurol 40:236-239 

Pan JW, Hetherington HP, Vaughan JT, Mitchell G, Pohost GM, Whitaker JN (1996) Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T. Magn Reson Med 36:72-77 

Pan JW, Mason GF, Pohost GM, Hetherington HP (1996) Spectroscopic imaging of human brain glutamate by water-suppressed J- refocused coherence transfer at 4.1 T. Magn Reson Med 36:7-12 

Hetherington H, Kuzniecky R, Pan J, Mason G, Morawetz R, Harris C, Faught E, Vaughan T, Pohost G (1995) Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T. Ann Neurol 38:396-404 

Hetherington HP, Luney DJ, Vaughan JT, Pan JW, Ponder SL, Tschendel O, Twieg DB, Pohost GM (1995) 3D 31P spectroscopic imaging of the human heart at 4.1 T. Magn Reson Med 33:427-431 

Hetherington HP, Kuzniecky RI, Pan JW, Vaughan JT, Twieg DB, Pohost GM (1995) Application of high field spectroscopic imaging in the evaluation of temporal lobe epilepsy. Magn Reson Imaging 13:1175-1180 

Balschi JA, Hetherington HP, Bradley EL, Jr., Pohost GM (1995) Water-suppressed one-dimensional 1H NMR chemical shift imaging of the heart before and after regional ischemia. NMR Biomed 8:79-86 

Mason GF, Pohost GM, Hetherington HP (1995) Numerically optimized experiment design for measurement of grey/white matter metabolite T2 in high-resolution spectroscopic images of brain [published erratum appears in J Magn Reson B 1996 Mar;110(3):321]. J Magn Reson B 107:68-73 

Pan JW, Vaughan JT, Kuzniecky RI, Pohost GM, Hetherington HP (1995) High resolution neuroimaging at 4.1T. Magn Reson Imaging 13:915-921