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Title   Radiation Therapy Sandwiched Between Paclitaxel and Carboplatin in Patients With High-risk Endometrial Cancer
Description   In this study, radiation is "sandwiched" between paclitaxel/carboplatin chemotherapy in attempts to decrease the chance of the cancer returning in the pelvis or elsewhere in the body.

This study will evaluate the tolerability of combining radiation with chemotherapy in this way. We will also evaluate any side effects that patients may experience with this treatment.



Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patient must be Female and 18 Years or older

* Patient must have histologically-documented high-risk endometrioid adenocarcinoma with no visible residual disease, defined by the following criteria:

- Surgical stage I disease with < 50 myometrial invasion and grade 3 tumor (IBG3) with lymphovascular space involvement;
- Surgical stage I disease with > 50% myometrial invasion and grade 2 or 3 tumor (ICG2, ICG3);
- Any surgical stage II disease (IIA, IIB);
- Any surgical stage III disease (IIIA, IIIB, IIIC); and
- Any surgical stage IV disease with no residual macroscopic tumor
Principal Investigator   Dennis Yi-Shin Kuo, MD
Contact Name   Loraine Centrilla, RN
Phone   (718) 405-8082
Contact Email   lcentril@montefiore.org
Post Date   12/29/2009
Protocol Number   08-03-060/West
Status   Recruiting
Current Trial Type   Interventional