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Title   Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer
Description   The purpose of this trial is to study how well giving radiation therapy, paclitaxel, and carboplatin together with or without trastuzumab works in treating patients with esophageal cancer.

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin , work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them.

It is not yet known whether giving radiation therapy and combination chemotherapy together with or without trastuzumab is more effective in treating esophageal cancer.
Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patient must be 18 Years and older

* Patient must have pathologically confirmed primary adenocarcinoma of the esophagus.
Principal Investigator   Lakshmi Rajdev, MD
Contact Name   Cheryl Baker, RN
Phone   (718) 405-8508
Contact Email   cbaker@montefiore.org
Post Date   09/04/2010
Protocol Number   2011-312/East
Status   Recruiting
Current Trial Type   Interventional
Adult Clinical Trial   No
Pediatric Clinical Trial   No