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Title   Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy
Description   The purpose of this trial is to study radiation therapy to see how well it works compared with or without trastuzumab in treating women with ductal carcinoma in situ who have undergone lumpectomy.

Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Radiation therapy uses high-energy x-rays to kill tumor cells.

It is not yet known whether radiation therapy is more effective with or without trastuzumab in treating ductal carcinoma in situ.
Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patient must be Female and 18 Years or older

* Patient must have histologically confirmed ductal carcinoma in situ (DCIS)

* Life expectancy = 10 years (excluding diagnosis of DCIS)

Principal Investigator   Madhur Garg, MD
Contact Name   Karen Fehn, RN
Phone   (718) 420-8446
Contact Email   kfehn@montefiore.org
Fax   (718) 405-8230
Post Date   10/08/2008
Protocol Number   09-10-318/West
Status   Recruiting
Current Trial Type   Interventional
Adult Clinical Trial   No
Pediatric Clinical Trial   No