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Title	Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer
Description	The purpose of this trial is to study how well giving radiation therapy, paclitaxel, and carboplatin together with or without trastuzumab works in treating patients with esophageal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin , work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether giving radiation therapy and combination chemotherapy together with or without trastuzumab is more effective in treating esophageal cancer.
Eligibility Criteria	To be eligible for this study, patients must meet several criteria, including but not limited to the following: * Patient must be 18 Years and older * Patient must have pathologically confirmed primary adenocarcinoma of the esophagus.
Principal Investigator	Lakshmi Rajdev, MD
Contact Name	Cheryl Baker, RN
Phone	(718) 405-8508
Contact Email	cbaker@montefiore.org
Post Date	09/04/2010
Protocol Number	2011-312/East
Status	Recruiting
Current Trial Type	Interventional