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Title   Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Disease/Condition   Head and Neck Cancer
Description   The purpose of the trial is to study chemotherapy and see how well it works with or without bevacizumab in treating patients with recurrent or metastatic head and neck cancer.

Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways.

Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor.

It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck cancer.
Eligibility Criteria   To be eligible for this study, patients must meet several criteria, including but not limited to the following:

* Patient must be 18 Years and older

* Patient must have histologically or cytologically confirmed squamous cell carcinoma of the head and neck (SCCHN) from any primary site, including unknown primary cancers of the head and neck.
Principal Investigator   Missak Haigentz, MD
Contact Name   Yoko Eng, NP
Phone   (718) 920-2090
Contact Email   yeng@montefiore.org
Post Date   12/28/2007
Protocol Number   2008-411/East
Status   Recruiting
Current Trial Type   Interventional