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Meet the Ophthalmology Physicians
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Eyes (Ophthalmology and Visual Sciences)

Meet the Ophthalmology Physicians

Cheng C. Zhang, MD

Ophthalmology and Visual Sciences
Practice Specialty
Ophthalmology (Eyes), Pediatrics - Ophthalmology (Eyes)
University of Illinois at Chicago
Johns Hopkins Medical Center
Academic Title
Assistant Professor
Administrative Title
Attending Physician
Clinical Focus
Dr. Zhang specializes in pediatric neuro-ophthalmology and strabismus. He is particularly interested in the following areas: congenital and acquired nystagmus; cranial nerve palsy with or without diplopia (double vision); hereditary optic nerve diseases (atrophy) or acquired optic neuropathy, and benign intracranial hypertension or psudotumor cerebri.
Research Focus
Dr. Zhang has been studying various forms of hereditary or acquired forms of optic nerve diseases and optic atrophy. He is actively conducting research on developing new therapy for optic nerve degenerative diseases.

View Dr. Zhang's publications on Pubmed

  1. Jing Y, Kumar PR, Zhu L, Edward DP, Tao S, Wang L, Chuck R, Zhang C*.  Novel decorin mutation in a Chinese family with congenital stromal corneal dystrophy. Cornea.  2014 March:33(3):288-93.
  2. Zhu L, Zhang C, Chuck RS.  Topical steroid and non-steroidal anti-inflammatory drugs inhibit inflammatory cytokine expression on the ocular surface in the botulinum toxin B-induced murine dry eye model.  Mol Vis. 2012;18:1803-12. PMID: 22815633
  3. Zhang C, Asnaghi L, Gongora C, et al.  A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.  Eur J Cell Biol. 2011 May;90(5):440-8.
  4. Zigler JS Jr, Zhang C, Grebe R, et al.  Mutation in the {beta}A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.  J Cell Sci. 2011 Feb 15;124(Pt 4):523-31.
  5. Zhou SY, Zhang C, Baradaran E, Chuck RS.  Human corneal basal epithelial cells express an embryonic stem cell marker OCT4.  Curr Eye Res. 2010 Nov;35(11):978-85.
  6. Zhang C, Phamonvaechavan P, Christoff A, Guyton DL.  Silent sinus syndrome causing cyclovertical diplopia masquerading as superior oblique paresis in the fellow eye. J AAPOS. 2010 Oct;14(5):450-2.
  7. Zhang C, Phamonvaechavan P, Rajan A, Poon DY, Topcu-Yilmaz P, Guyton DL. Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle. J AAPOS. 2010 Aug;14(4):323-7.
  8. Zhang C, Guo Y, Slater BJ, Miller NR, Bernstein SL. Axonal degeneration, regeneration and ganglion cell death in a rodent model of anterior ischemic optic neuropathy (rAION). Exp Eye Res. 2010 Aug;91(2):286-92.
  9. Zhang C, Guo Y, Miller NR, and Bernstein SL.  Optic nerve infarction and post-ischemic inflammation in the rodent model of anterior ischemic optic neuropathy (rAION).  Brain Res.  2009;1264:67-75.
  10. Zhang C, DiBernardo C, Miller NR. Pseudo-Cerebrospinal Fluid Sign on Magnetic Resonance Imaging in a Patient with a Presumed Optic Nerve Sheath Meningioma.  Neuro-Ophthalmology.  2008;32:266-269.
  11. Suh LH, Zhang C, Chuck RS, Stark WJ, Naylor S, Binley K, Chakravarti S, Jun AS. Cryopreservation and lentiviral-mediated genetic modification of human primary cultured corneal endothelial cells. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3056-61.
  12. Coassin M, Zhang C, Green WR, Aquavella JV, Akpek EK. Histopathologic and immunologic aspects of alphacor artificial corneal failure. Am J Ophthalmol. 2007 Nov;144(5):699-704.
  13. Zhang C, Bell WR, Sundin OH, De La Cruz Z, Stark WJ, Green WR, Gottsch JD. Immunohistochemistry and electron microscopy of early-onset fuchs corneal dystrophy in three cases with the same L450W COL8A2 mutation. Trans Am Ophthalmol Soc. 2006;104:85-97.
  14. Zhang C*, Lam TT, Tso MO. Heterogeneous populations of microglia/macrophages in the retina and their activation after retinal ischemia and reperfusion injury. Exp Eye Res. 2005 Dec;81(6):700-9. (corresponding author)
  15. Zhang C*, Shen JK, Lam TT, Zeng HY, Chiang SK, Yang F, Tso MO. Activation of microglia and chemokines in light-induced retinal degeneration. Mol Vis. 2005 Oct 27;11:887-95. (*corresponding author)
  16. Zhang C, Gehlbach P, Gongora C, Cano M, Fariss R, Hose S, Nath A, Green WR, Goldberg MF, Zigler JS Jr, Sinha D. A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye. Developmental Dynamics. 2005 Sep;234(1):36-47.
  17. Gottsch JD, Zhang C, Sundin OH, Bell WR, Stark WJ, Green WR. Fuchs corneal dystrophy: aberrant collagen distribution in an L450W mutant of the COL8A2 gene. Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4504-11.
  18. Zhang C*, Lei B, Lam TT, Yang F, Sinha D, Tso MOM.  Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration.  Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2753-9. (corresponding author)
  19. Zhang C* and Tso MOM.  Characterization of activated retinal microglia following optic axotomy.  J Neurosci Res. 2003 Sep 15; 73(6): 840-5. (corresponding author)
  20. Chen YG, Zhang C, Chiang SK, Wu T, Tso MO. Increased nuclear factor-kappaB p65 immunoreactivity following retinal ischemia and reperfusion injury in mice. J Neurosci Res 2003 Apr 1;72(1):125-31
  21. Zhang C, Rosenbaum DM, Shaikh AR, Li Q, Rosenbaum PS, Pelham DJ, Roth S. Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Invest Ophthalmol Vis Sci 2002 Sep;43(9):3059-66 
  22. Zhang C, Takahashi K, Lam TT, and Tso MOM.  Effects of basic fibroblast growth factor on retinal ischemia.  Invest Ophthalmol & Vis Sci  1994;35:3163-68.
  23. Tso MOM, Zhang C, Abler A, et al.  Apoptosis leads to the photoreceptor degeneration in RCS rats.  Invest Ophthalmol & Vis Sci  1994;35:2693-99.
  24. Zhang C, Ticho KE, Ticho BH, et al.  Mucoepidermoid carcinoma of the eyelid skin.  Ophthalmol Plast Reconstr Surg 1999;15(5):369-72.
Cheng (Charles) Zhang, MD, graduated from Henan Medical University in China, where he also completed an ophthalmology residency. He was then awarded a WHO (World Health Organization) fellowship and spent 2 years as ocular pathology fellow at University of Illinois at Chicago. He also finished two years of clinical fellowship of pediatric ophthalmology and neuro-ophthalmology at the Wilmer Eye Institute at Johns Hopkins Hospital. He joined the Montefiore in 2010.